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Full-Text Articles in Public Health
Fetal Growth Restriction: Molecular Mechanisms And Long-Term Outcomes, Caroline D. Albion
Fetal Growth Restriction: Molecular Mechanisms And Long-Term Outcomes, Caroline D. Albion
Electronic Thesis and Dissertation Repository
Fetal undernutrition is a major factor in the pathophysiology of fetal growth restriction (FGR) in many species, including humans. Our hypothesis is that mild maternal nutrient restriction (MNR) in a mouse provides a clinically relevant model to study FGR mechanisms and long-term effects similar to humans and the developmental origins of health and disease (DOHaD) predisposition. A MNR mouse model of FGR was developed by feeding mothers 70% normal daily caloric intake during E6.5 to E18.5 gestation. Significant reduction in fetal weight and fetal liver and lung weights with less impact on brain weight resulted, similar to asymmetric human FGR. …
Depressive Symptoms In Mothers Of Children With New-Onset Epilepsy: A Prospective Study, Mark Anthony Ferro
Depressive Symptoms In Mothers Of Children With New-Onset Epilepsy: A Prospective Study, Mark Anthony Ferro
Electronic Thesis and Dissertation Repository
Having a child diagnosed with a chronic illness such as epilepsy is a major source of stress for caregivers. Up to half of mothers of children with epilepsy are at increased risk for clinical depression and symptoms of maternal depression are associated with poorer health outcomes in these children. The purpose of this study was to: 1) estimate the prevalence and course of depressive symptoms over 24 months among mothers of children with new-onset epilepsy; 2) identify subgroups of mothers that share similar trajectories of depressive symptoms; and, 3) assess the family factors involved in the causal pathway between maternal …