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Articles 1 - 10 of 10
Full-Text Articles in Public Health
Maternal Prenatal Cortisol Programs The Infant Hypothalamic–Pituitary–Adrenal Axis, Jessica L. Irwin, Amy L. Meyering, Gage Peterson, Laura M. Glynn, Curt A. Sandman, Laurel M. Hicks, Elysia Poggi Davis
Maternal Prenatal Cortisol Programs The Infant Hypothalamic–Pituitary–Adrenal Axis, Jessica L. Irwin, Amy L. Meyering, Gage Peterson, Laura M. Glynn, Curt A. Sandman, Laurel M. Hicks, Elysia Poggi Davis
Psychology Faculty Articles and Research
One of the key proposed agents of fetal programming is exposure to maternal glucocorticoids. Experimental animal studies provide evidence that prenatal exposure to elevated maternal glucocorticoids has consequences for hypothalamic–pituitary–adrenal (HPA) axis functioning in the offspring. There are very few direct tests of maternal glucocorticoids, such as cortisol, during human pregnancy and associations with infant cortisol reactivity. The current study examined the link between maternal prenatal cortisol trajectories and infant cortisol reactivity to the pain of inoculation in a sample of 152 mother-infant (47.4% girls) pairs. The results from the current study provide insight into fetal programming of the infant …
Characterizing Prenatal Maternal Distress With Unique Prenatal Cortisol Trajectories, Gage Peterson, Emma V. Espel, Elyssia Poggi Davis, Curt A. Sandman, Laura M. Glynn
Characterizing Prenatal Maternal Distress With Unique Prenatal Cortisol Trajectories, Gage Peterson, Emma V. Espel, Elyssia Poggi Davis, Curt A. Sandman, Laura M. Glynn
Psychology Faculty Articles and Research
Objective: It is widely assumed that glucocorticoids represent a primary mechanism through which exposure to adversity and maternal psychological distress shape prenatal developmental trajectories of both mother and fetus. However, despite repeated investigations and the fact that prenatal cortisol has been reliably linked to developmental outcomes, the empirical evidence supporting an association between prenatal cortisol and maternal distress is scarce. In this study, a novel approach to assessing links between maternal prenatal psychological distress and gestational cortisol profiles, general growth mixture modeling (GGMM), was applied. Method: Measures of pregnancy anxiety, perceived stress, and state anxiety and depressive symptoms as well …
Cesarean Delivery And Infant Cortisol Regulation, Leticia D. Martinez, Laura M. Glynn, Curt A. Sandman, Deborah A. Wing, Elysia Poggi Davis
Cesarean Delivery And Infant Cortisol Regulation, Leticia D. Martinez, Laura M. Glynn, Curt A. Sandman, Deborah A. Wing, Elysia Poggi Davis
Psychology Faculty Articles and Research
Background:
Cesarean delivery reduces the risk of infant and maternal morbidity and mortality when medically indicated, however, the cesarean delivery rate is estimated to be two to three times higher than medically necessary. The World Health Organization and American College of Obstetricians and Gynecologists have expressed concern over the high rates of cesarean delivery, citing evidence that cesarean delivery has negative short- and long-term consequences for the health of the infant, mother, and for future pregnancies. Infants delivered by cesarean are at an increased risk of metabolic disease and immune dysfunction throughout the lifespan. Preliminary research suggests that the …
Fertility Awareness And Parenting Intentions Among Mexican Undergraduate And Graduate University Students, J. M. Place, Brennan D. Peterson, B. Horton, M. Sanchez
Fertility Awareness And Parenting Intentions Among Mexican Undergraduate And Graduate University Students, J. M. Place, Brennan D. Peterson, B. Horton, M. Sanchez
Marriage and Family Therapy Faculty Articles and Research
An online, cross-sectional survey was carried out between November 2017 and January 2018 to assess fertility awareness among students attending the National Autonomous University of Mexico (UNAM) in Mexico City. A total of 371 students participated in the survey (n = 228 females, 143 males). 75% of females and 74% of males believed a woman’s fertility begins to decline markedly after age 40. Over 75% of all participants overestimated the probability of couples having a live birth after undergoing one cycle of IVF. With regard to parenting intentions, only 48% of females wished to have children compared to 59% …
Immune Function During Pregnancy Varies Between Ecologically Distinct Populations, Carmen Hové, Benjamin C. Trumble, Amy S. Anderson, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven, Aaron Blackwell
Immune Function During Pregnancy Varies Between Ecologically Distinct Populations, Carmen Hové, Benjamin C. Trumble, Amy S. Anderson, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven, Aaron Blackwell
ESI Publications
Background and objectives
Among placental mammals, females undergo immunological shifts during pregnancy to accommodate the fetus (i.e. fetal tolerance). Fetal tolerance has primarily been characterized within post-industrial populations experiencing evolutionarily novel conditions (e.g. reduced pathogen exposure), which may shape maternal response to fetal antigens. This study investigates how ecological conditions affect maternal immune status during pregnancy by comparing the direction and magnitude of immunological changes associated with each trimester among the Tsimane (a subsistence population subjected to high pathogen load) and women in the USA.
Methodology
Data from the Tsimane Health and Life History Project (N = 935) and …
Mode Of Delivery And Infant Cognitive Development, Madison Olson, Laura M. Glynn
Mode Of Delivery And Infant Cognitive Development, Madison Olson, Laura M. Glynn
Student Scholar Symposium Abstracts and Posters
The rate of nonindicated cesarean births is increasing each year within the United States. Although cesarean delivery can function as a life- saving intervention, emerging evidence suggests that it may also be associated with deleterious developmental consequences for the child. Here we test the hypothesis that mode of delivery is associated with cognitive development during infancy. 229 pregnant women were recruited and their infants’ cognitive development was assessed at 6, 12 and 24 months with the Bayley Scales of Infant Development. Medical charts were reviewed by obstetric nurses to determine prenatal medical risk and birth outcomes, including mode of delivery. …
Maternal Depressive Symptoms Predict General Liability In Child Psychopathology, Danielle A. Swales, Hannah R. Snyder, Benjamin L. Hankin, Curt A. Sandman, Laura M. Glynn, Elyssia Poggi Davis
Maternal Depressive Symptoms Predict General Liability In Child Psychopathology, Danielle A. Swales, Hannah R. Snyder, Benjamin L. Hankin, Curt A. Sandman, Laura M. Glynn, Elyssia Poggi Davis
Psychology Faculty Articles and Research
Objective: The current study examines how maternal depressive symptoms relate to child psychopathology when structured via the latent bifactor model of psychopathology, a new organizational structure of psychopathological symptoms consisting of a general common psychopathology factor (p-factor) and internalizing- and externalizing-specific risk.
Method: Maternal report of depressive symptoms (Beck Depression Inventory – II) and child psychopathological symptoms (Child Behavior Checklist and Children’s Behavior Questionnaire) were provided by 554 mother-child pairs. Children in the sample were 7.7 years old on average (SD = 1.35, range = 5–11 years), and were 49.8% female, 46% Latinx, and 67% …
Characterization Of Extracellular Vesicles Isolated From Human Milk Using A Precipitation-Based Method, Diana C. Bickmore, John Miklavcic
Characterization Of Extracellular Vesicles Isolated From Human Milk Using A Precipitation-Based Method, Diana C. Bickmore, John Miklavcic
Food Science Faculty Articles and Research
Extracellular vesicles (EV) function in intercellular communication, and those in human milk may confer immunologic benefits to infants. Methods of EV isolation such as ultracentrifugation (UC) may not be feasible for the study of EVs in human milk due to the need for large sample volume. A technique to isolate EVs from a small volume of human milk using a precipitation reagent is described herein. Electron microscopy, nanoparticle tracking analysis, and semi-quantitative antibody array were conducted to confirm isolation of human milk EVs. Count, size, protein content, and fatty acid quantification of EVs were determined. This isolation technique yielded 8.9 …
Unpredictable Maternal Behavior Is Associated With A Blunted Infant Cortisol Response, Amanda N. Noroña-Zhou, Alyssa Morgan, Laura M. Glynn, Curt A. Sandman, Tallie Z. Baram, Hal S. Stern, Elyssia Poggi Davis
Unpredictable Maternal Behavior Is Associated With A Blunted Infant Cortisol Response, Amanda N. Noroña-Zhou, Alyssa Morgan, Laura M. Glynn, Curt A. Sandman, Tallie Z. Baram, Hal S. Stern, Elyssia Poggi Davis
Psychology Faculty Articles and Research
Background
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with poor physical and mental health. Early-life adversity may dysregulate cortisol response to subsequent stress. This study examines the association between patterns of maternal behavior and infant stress response to a challenge. Specifically, we test whether infant exposure to unpredictable maternal sensory signals is related to the cortisol response to a painful stressor.
Method
Participants were 102 mothers and their children enrolled in a longitudinal study. Patterns of maternal sensory signals were evaluated at 6 and 12 months during a 10-min mother–infant play episode. Entropy rate was calculated as a quantitative …
Insights Into Novel Infant Milk Formula Bioactives, Jordan Skolnick, Claire Chou, John Miklavcic
Insights Into Novel Infant Milk Formula Bioactives, Jordan Skolnick, Claire Chou, John Miklavcic
Food Science Faculty Articles and Research
Human milk provides optimal infant nutrition for early life development. However, there are situations in which human milk feeding is not the most viable option for infant nutrition. Some factors include maternal illness, lactation insufficiency, storage complications, and time constraints. As a result, modern infant formula has become a substitute or alternative when breastfeeding is not possible or is inadequate for infants. In the optimal design of formula, many factors are considered in creating a product that is safe and provides a nutritional profile either equivalent to human milk or in optimal alignment with infant needs. Human milk composition serves …