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Urinary Melatonin Levels And Risk Of Postmenopausal Breast Cancer In The Women's Health Initiative Observational Study, Ashley Doherty
Urinary Melatonin Levels And Risk Of Postmenopausal Breast Cancer In The Women's Health Initiative Observational Study, Ashley Doherty
Masters Theses 1911 - February 2014
Prior studies have observed a link between night shift work and increased risk of breast cancer. Melatonin, a hormone related to circadian rhythm, has been proposed to lower breast cancer risk by inhibiting cell proliferation. The disruption of peak melatonin that occurs during night shift work could explain the increase in risk observed. Several studies have assessed whether higher melatonin levels are associated with decreased breast cancer risk, but results have been conflicting. We examined the relationship between urinary melatonin levels and breast cancer risk in a nested case-control study conducted within the Women’s Health Initiative Observational Study. First morning …
The Impact Of Gestational Diabetes On Maternal And Cord Blood Lipids Among Prenatal Care Patients In Western Ma, Preethi Raj
The Impact Of Gestational Diabetes On Maternal And Cord Blood Lipids Among Prenatal Care Patients In Western Ma, Preethi Raj
Masters Theses 1911 - February 2014
Gestational diabetes mellitus (GDM), a pregnancy-induced metabolic disorder that affects 2-10% of pregnancies poses future risk for diabetes mellitus (DM) and cardiovascular disease in mother and child. However, few prospective studies have examined the effect of GDM on altered maternal and cord blood lipids, specifically HDL, LDL, triglycerides, and total cholesterol, both during and after pregnancy. We have evaluated the association between GDM and lipid metabolism in pregnant mothers and their infants using data from a prospective cohort study conducted at Baystate Medical Center’s Wesson Women and Infant’s Unit. GDM was assessed prenatally by 3-hr GTT blood samples and was …