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Behavior and Behavior Mechanisms Commons™
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Full-Text Articles in Behavior and Behavior Mechanisms
Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio
Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio
Honors Scholar Theses
Tetrabenazine (TBZ), a vesicular monoamine transporter type 2 (VMAT-2) inhibitor, depletes dopamine and induces motivational deficits and other depressive symptoms in humans. Methylphenidate (MPH) is a dopamine transport blocker that is used to enhance motivational function. Previous studies have shown that in male rats, TBZ induces a shift in effort-related choice such that a low-effort bias is induced. In male rats this occurs at a dose range of 0.75-1.0 mg/kg TBZ, and this effect is reversible with co-administration of MPH. Recent studies have shown that females need a higher dose of TBZ (2.0 mg/kg) to show the low-effort bias. The …
Assessing Rat Behavioral Response To Novelty, Neha Mathew
Assessing Rat Behavioral Response To Novelty, Neha Mathew
Honors Scholar Theses
The hippocampus is the part of the brain that is involved in memory and navigation. Neurons in the hippocampus, known as place cells, fire in specific locations within this region of the brain as the subject navigates through their environment. As these cells fire, they create a map-like representation of this environment. However if the environment is altered in any way, the place cell firing pattern is adjusted to incorporate this new information. This adjustment will inevitably cause subjects to take more time to complete their task. The goal of our testing was to assess how various manipulations, both spatial …