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Full-Text Articles in Psychiatry and Psychology
Pentylenetetrazol Produces A State-Dependent Conditioned Place Aversion To Alcohol Withdrawal In Mice, Julia Chester, Laran E. Coon
Pentylenetetrazol Produces A State-Dependent Conditioned Place Aversion To Alcohol Withdrawal In Mice, Julia Chester, Laran E. Coon
Department of Psychological Sciences Faculty Publications
The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABAA receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific line selectively bred for low alcohol preference (LAP1; n=91) and were assigned to three groups: alcohol withdrawal, PTZ alone, and PTZ + alcohol withdrawal. On four trials, mice received either a 4.0 g/kg intraperitoneal (i.p.) injection of alcohol (alcohol withdrawal, PTZ + alcohol withdrawal …
Effects Of The Novel Endocannabinoid Uptake Inhibitor, Ly2183240, On Fear-Potentiated Startle And Alcohol-Seeking Behaviors In Mice Selectively Bred For High Alcohol Preference, Matthew S. Powers, G. D. Barrenha, N. S. Mlinac, Eric L. Barker, Julia Chester
Effects Of The Novel Endocannabinoid Uptake Inhibitor, Ly2183240, On Fear-Potentiated Startle And Alcohol-Seeking Behaviors In Mice Selectively Bred For High Alcohol Preference, Matthew S. Powers, G. D. Barrenha, N. S. Mlinac, Eric L. Barker, Julia Chester
Department of Psychological Sciences Faculty Publications
Rationale Alcohol-use disorders often occur together with anxiety disorders in humans which may be partly due to common inherited genetic factors. Evidence suggests that the endocannabinoid system (ECS) is a promising therapeutic target for the treatment of individuals with anxiety and/or alcohol-use disorders. Objectives The present study assessed the effects of a novel endocannabinoid uptake inhibitor, LY2183240, on anxiety- and alcohol-seeking behaviors in a unique animal model that may represent increased genetic risk to develop co-morbid anxiety and alcohol-use disorders in humans. Mice selectively bred for high alcohol preference (HAP) show greater fear-potentiated startle (FPS) than mice selectively bred for …