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A Randomized Controlled Trial Of Quetiapine Versus Placebo In The Treatment Of Delirium, Tayyeb Tahir, Eamonn Eeles, Venugopal Karapareddy, Prem Muthuvelu, Sian Chapple, Bethan Phillips, Toyin Adyemo, Daniel Farewell, Jonathan I. Bisson
A Randomized Controlled Trial Of Quetiapine Versus Placebo In The Treatment Of Delirium, Tayyeb Tahir, Eamonn Eeles, Venugopal Karapareddy, Prem Muthuvelu, Sian Chapple, Bethan Phillips, Toyin Adyemo, Daniel Farewell, Jonathan I. Bisson
Brain and Mind Institute
Background
Delirium is a commonly occurring complex neuropsychiatric disorder. Evidence for its treatment based on randomized controlled trials (RCTs) is poor.
Aims
To determine the efficacy and acceptability of quetiapine in the treatment of delirium.
Method
A double-blind, RCT was conducted. A total of 42 patients were randomized to quetiapine or a placebo group. The primary outcome measure was the Delirium Rating Scale Revised 98. Other scales used were the Brief Psychiatric Rating Scale, Mini-Mental State Examination and Clinical Global Improvement. In order to account for missing data, a nonlinear mixed-effects model was used to estimate the difference …