Psychiatry and Psychology Commons^™

Reduced Neural Activation During An Inhibition Task Is Associated With Impaired Fear Inhibition In A Traumatized Civilian Sample, Tanja Jovanovic, Tim Ely, Negar Fani, Ebony Glover, David Gutman, Erin Tone, Seth D. Norrholm, Bekh Bradley, Kerry J. Ressler

Psychology Faculty Publications

Introduction: Impaired inhibition of fear in the presence of safety cues and a deficiency in the extinction of fear cues are increasingly thought to be important biological markers of Posttraumatic Stress Disorder (PTSD). Other studies have suggested that there may be altered neural activation during behavioral inhibition tasks in subjects with PTSD. The current study aimed to see whether neural activation during inhibition was reduced in a highly traumatized civilian population, and whether atypical activation was associated with impaired fear inhibition.

Methods: The participants were 41 traumatized women (20 PTSD+, 21 PTSD-) recruited from Grady Memorial Hospital in …

Fkbp5 Modulates Attention Bias For Threat: Associations With Hippocampal Function And Morphology, Negar Fani, David Gutman, Erin Tone, Lynn Almli, Kristina B. Mercer, Jennifer Davis, Ebony Glover, Tanja Jovanovic, Bekh Bradley, Ivo D. Dinov, Alen Zamanyan, Arthur W. Toga, Elisabeth B. Binder, Kerry J. Ressler

Psychology Faculty Publications

Context: The FKBP5 gene product regulates glucocorticoid receptor (GR) sensitivity and hypothalamicpituitary‐adrenal axis functioning, and has been associated with a number of stress‐related psychiatric disorders. The study of intermediate phenotypes, such as emotion‐processing biases and their neural substrates, provides a way to clarify the mechanisms by which FKBP5 dysregulation mediates psychopathology risk.

Objective: To examine whether allelic variations for a putatively functional SNP associated with FKBP5 gene regulation (rs1360780) would relate differentially to attentional bias for threat; this was measured through behavioral response on a dot probe task and hippocampal activation during task performance. Morphological substrates of differential hippocampal response …

Neural Responses To Peer Rejection In Anxious Adolescents: Contributions From The Amygdala-Hippocampal Complex, Jennifer Y.F. Lau, Amanda E. Guyer, Erin Tone, Jessica Jenness, Jessica M. Parrish, Daniel S. Pine, Eric E. Nelson

Psychology Faculty Publications

Peer rejection powerfully predicts adolescent anxiety. While cognitive differences influence anxious responses to social feedback, little is known about neural contributions. Twelve anxious and 12 age-, gender- and IQ-matched, psychiatrically-healthy adolescents received ‘not interested’ and ‘interested’ feedback from unknown peers during a Chatroom task administered in a neuroimaging scanner. No group differences emerged in subjective ratings to peer feedback, but all participants reported more negative emotion at being rejected (than accepted) by peers to whom they had assigned high desirability ratings. Further highlighting the salience of such feedback, all adolescents, independent of anxiety levels, manifested elevated responses in the amygdala-hippocampal …