Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Psychiatry and Psychology
Using Heart Rate Profiles During Sleep As A Biomarker Of Depression, Mysa Saad, Laura B. Ray, Brad Bujaki, Amir Parvaresh, Iryna Palamarchuk, Joseph De Koninck, Alan Douglass, Elliott K. Lee, Louis J. Soucy, Zul Merali
Using Heart Rate Profiles During Sleep As A Biomarker Of Depression, Mysa Saad, Laura B. Ray, Brad Bujaki, Amir Parvaresh, Iryna Palamarchuk, Joseph De Koninck, Alan Douglass, Elliott K. Lee, Louis J. Soucy, Zul Merali
Brain and Mind Institute
Background: Abnormalities in heart rate during sleep linked to impaired neuro-cardiac modulation may provide new information about physiological sleep signatures of depression. This study assessed the validity of an algorithm using patterns of heart rate changes during sleep to discriminate between individuals with depression and healthy controls.
Methods: A heart rate profiling algorithm was modeled using machine-learning based on 1203 polysomnograms from individuals with depression referred to a sleep clinic for the assessment of sleep abnormalities, including insomnia, excessive daytime fatigue, and sleep-related breathing disturbances (n = 664) and mentally healthy controls (n = 529). The final algorithm …