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Psychiatry and Psychology Commons

Open Access. Powered by Scholars. Published by Universities.®

Social and Behavioral Sciences

2012

Antidepressants

Articles 1 - 2 of 2

Full-Text Articles in Psychiatry and Psychology

Four Potential Criteria For Deciding When To Use Antidepressants Or Psychotherapy For Unipolar Depression: A Literature Review, Christopher Sharpley, Vicki Bitsika Sep 2012

Four Potential Criteria For Deciding When To Use Antidepressants Or Psychotherapy For Unipolar Depression: A Literature Review, Christopher Sharpley, Vicki Bitsika

Vicki Bitsika

Objective: To evaluate the literature supporting four potential criteria for deciding whether to use psychotherapy or pharmacology when treating depression.

Method: Literature review of the evidence from the last 10 years on presenting patient’s demographics, aetiology, comorbidity, and genetic factors, as predictors of treatment outcome efficacy.

Results: Demographic information has little support as a potential criteria for decision-making; aetiology (melancholic vs. non-melancholic) has significant support; presence of personality disorder comorbidity is unproven as a criterion but may have some value; genetic predisposition has the strongest evidence supporting it as a criteria for treatment decision-making.

Conclusion: Although some presenting cases will …


Taking The Perspective That A Depressive State Reflects Inflammation: Implications For The Use Of Antidepressants, Jill Littrell Aug 2012

Taking The Perspective That A Depressive State Reflects Inflammation: Implications For The Use Of Antidepressants, Jill Littrell

SW Publications

This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term efficacy of antidepressants, which have short term anti-inflammatory effects. Evidence for those anti-inflammatory effects is discussed. Evidence of the contrary long-term effects of antidepressants, which increase rather than decrease inflammation, is also reviewed. It is argued that this increase in inflammation would predict an increase in chronicity among depressed patients that have been treated with antidepressants drugs, which has …