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Full-Text Articles in Other Medicine and Health Sciences
Aging Induces Profound Changes In Sncrna In Rat Sperm And These Changes Are Modified By Perinatal Exposure To Environmental Flame Retardant, Alexander Suvorov, J. Richard Pilsner, Vladimir Naumov, Victoria Shtratnikova, Anna Zheludkevich, Evgeny Gerasimov, Maria Logachev, Oleg Sergeyev
Aging Induces Profound Changes In Sncrna In Rat Sperm And These Changes Are Modified By Perinatal Exposure To Environmental Flame Retardant, Alexander Suvorov, J. Richard Pilsner, Vladimir Naumov, Victoria Shtratnikova, Anna Zheludkevich, Evgeny Gerasimov, Maria Logachev, Oleg Sergeyev
Environmental Health Sciences Faculty Publication Series
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may be linked to age-related epigenetic changes in the father’s sperm. An understanding of aging-related epigenetic changes in sperm and environmental factors that modify such changes is needed. Here, we characterize changes in sperm small non-coding RNA (sncRNA) between young pubertal and mature rats. We also analyze the modification of these changes by exposure to environmental xenobiotic 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47). sncRNA libraries prepared from epididymal spermatozoa were sequenced and analyzed using DESeq 2. The distribution of small RNA fractions changed with age, with fractions mapping …
Hormesis And Ginseng: Ginseng Mixtures And Individual Constituents Commonly Display Hormesis Dose Responses, Especially For Neuroprotective Effects, Edward Calabrese Ph.D.
Hormesis And Ginseng: Ginseng Mixtures And Individual Constituents Commonly Display Hormesis Dose Responses, Especially For Neuroprotective Effects, Edward Calabrese Ph.D.
Environmental Health Sciences Faculty Publication Series
This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prevent cardiovascular system damage, protect the kidney from toxicities due to immune suppressant drugs, and prevent corneal damage, amongst other examples. These …