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Absolute And Relative Changes (Delta) In Troponin I For Early Diagnosis Of Myocardial Infarction: Results Of A Prospective Multicenter Trial., Alan B Storrow, Richard M Nowak, Deborah B Diercks, Adam J Singer, Alan H B Wu, Erik Kulstad, Frank Lovecchio, Christian Fromm, Gary Headden, Tracie Potis, Christopher J Hogan, Jon W Schrock, Daniel P Zelinski, Marna Greenberg, Robert H Christenson, James C Ritchie, Janna S Chamberlin, Kurtis R Bray, Daniel W Rhodes, Deirdre Trainor, Paula C Southwick

Marna R Greenberg DO, MPH, FACEP

OBJECTIVES: We investigated absolute and relative cardiac troponin I (TnI) delta changes, optimal sampling protocols, and decision thresholds for early diagnosis of myocardial infarction (MI). Serial cardiac biomarker values demonstrating a rise and/or fall define MI diagnosis; however the magnitude of change, timing, and diagnostic accuracy of absolute versus relative (percentage) deltas remains unsettled. METHODS: We prospectively measured TnI (AccuTnI+3™, Beckman Coulter) at serial time intervals in 1929 subjects with chest pain or equivalent symptoms of acute coronary syndrome at 14 medical centers. Diagnosis was adjudicated by an independent central committee. RESULTS: Elevated TnI above a threshold of 0.03ng/mL demonstrated …