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Analysis And Diagnostic Implications Of The Fusion And Attachment Protein Genes Of Respiratory Syncytial Viruses Of Ruminants, Nasser Zakaria Eleraky

Doctoral Dissertations

Respiratory syncytial viruses (RSVs) in ruminants are classified into two subgroups, ovine RSV and bovine RSV. Although ovine RSV infects cattle, its contribution to bovine respiratory tract disease has not been established which is an important issue for vaccine development in cattle.

Diagnosis by virus isolation or serology has low or variable sensitivity and/or specificity and PCR has been recommended as a rapid and sensitive technique for RSV detection. Prior to this study, a laboratory test to differentiate between bovine and ovine RSVs did not exist.

First, the nucleotide sequence of the ovine RSV fusion (F) gene was determined and …