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Expression And Characterization Of The Mhc Class Ii Transactivator In K-562 Cells, Noel Elyssa Day
Expression And Characterization Of The Mhc Class Ii Transactivator In K-562 Cells, Noel Elyssa Day
Doctoral Dissertations
The K-562 cell line was developed from the pleural effusion of a patient with chronic myelogenous leukemia (CML) in blast crisis and has served as an excellent model to study the properties of CML cells. The highly undifferentiated cells can be induced by a variety of chemicals to follow multiple pathways of differentiation. When K-562 cells were treated with phorbol myristate acetate (PMA), they exhibited accessory cell functions by replacing monocytes in the activation of resting Th2 lymphocytes. However, K-562 cells are negative for the expression of class II major histocompatibility complex (MHC) antigens HLA-DR, -DP, and -DQ. The focus …