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Articles 1 - 4 of 4
Full-Text Articles in Organisms
Bacterial Rna:Dna Hybrids Are Activators Of The Nlrp3 Inflammasome, Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian M. Skehan, Katherine A. Fitzgerald, John M. Leong
Bacterial Rna:Dna Hybrids Are Activators Of The Nlrp3 Inflammasome, Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian M. Skehan, Katherine A. Fitzgerald, John M. Leong
Katherine A. Fitzgerald
Enterohemorrhagic Escherichia coli (EHEC) is an extracellular pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. The proinflammatory cytokine, interleukin-1beta, has been linked to hemolytic uremic syndrome. Here we identify the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome as an essential mediator of EHEC-induced IL-1beta. Whereas EHEC-specific virulence factors were dispensable for NLRP3 activation, bacterial nucleic acids such as RNA:DNA hybrids and RNA gained cytosolic access and mediated inflammasome-dependent responses. Consistent with a direct role for RNA:DNA hybrids in inflammasome activation, delivery of synthetic EHEC RNA:DNA hybrids into the cytosol triggered NLRP3-dependent responses, …
Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Erich Yahner, MSLIS
No abstract provided.
Hsisp Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Hsisp Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Erich Yahner
No abstract provided.
Hsisp Annotated Bibliography: Attitudes Toward Animals (1998-2013), Erich Yahner
Hsisp Annotated Bibliography: Attitudes Toward Animals (1998-2013), Erich Yahner
Erich Yahner, MSLIS
No abstract provided.