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Organisms Commons

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Animals

Animal Studies

2016

Articles 1 - 3 of 3

Full-Text Articles in Organisms

An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls Sep 2016

An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Jarrod Bailey, PhD

Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive data set of 2,366 drugs, for which both animal and human data are available, including tissue-level effects and MedDRA Level 1–4 biomedical observations. This was done for three preclinical species (rat, mouse …


Wild Justice Redux: What We Know About Social Justice In Animals And Why It Matters, Jessica Pierce, Marc Bekoff Sep 2016

Wild Justice Redux: What We Know About Social Justice In Animals And Why It Matters, Jessica Pierce, Marc Bekoff

Marc Bekoff, PhD

Social justice in animals is beginning to attract interest in a broad range of academic disciplines. Justice is an important area of study because it may help explain social dynamics among individuals living in tightly- knit groups, as well as social interactions among individuals who only occasionally meet. In this paper, we provide an overview of what is currently known about social justice in animals and offer an agenda for further research. We provide working definitions of key terms, outline some central research questions, and explore some of the challenges of studying social justice in animals, as well as the …


The Ethics Of Wildlife Control In Humanized Landscapes, John Hadidian, Camilla H. Fox, William S. Lynn Aug 2016

The Ethics Of Wildlife Control In Humanized Landscapes, John Hadidian, Camilla H. Fox, William S. Lynn

William S. Lynn, PhD

The 21st century is witness to an unprecedented and rapid growth of human settlements, from urban centers to wilderness vacation resorts. Concurrent with this has been the growing tolerance and acceptance of many wild animals and humans for one another. This has created an expanding ‘zone’ of human-animal contacts, some number of which invariably result in conflicts. While the vast majority of our interactions with wild animals are undoubtedly benign, it is the conflict between wildlife and people that draws particularly close attention from the public. Animals viewed as vertebrate “pests” range from the small to the large, the timid …