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Articles 1 - 4 of 4
Full-Text Articles in Organisms
Interactions Of Francisella Tularensis With Components Of The Host Fibrinolytic System, Shawn Russell Clinton
Interactions Of Francisella Tularensis With Components Of The Host Fibrinolytic System, Shawn Russell Clinton
Theses and Dissertations (ETD)
Francisella tularensis (FT) is a Gram-negative coccobacillus and causative agent of a life-threatening disease commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of bioterrorism, this bacterium is listed as a Category A select agent by the Centers for Disease Control and Prevention (CDC). Efforts to understand the pathogenic mechanisms of FT within the host environment are vital for the development of safe and effective vaccines, as well as treatments, against tularemia. Though considered an intracellular pathogen, FT research of late has …
Methicillin Resistance In Staphylococcus Pseudintermedius, Chad Christopher Black
Methicillin Resistance In Staphylococcus Pseudintermedius, Chad Christopher Black
Doctoral Dissertations
Staphylococcus pseudintermedius affecting dogs is analogous to S. aureus on humans, acting as both normal flora and opportunistic pathogen. Methicillin resistance in S. pseudintermedius is recent, with the first documented occurrence of an isolate bearing the methicillin resistance gene, mecA, in 1999. This gene encodes penicillin binding protein 2a, which renders all beta-lactam drugs ineffective and functions as a “gateway” antibiotic resistance determinant. In the presence of ineffective antibiotics, opportunities for mutational events and acquisition of mobile genetic elements increase as microbial densities increase, often leading to multi-drug resistance. Methicillin-resistant S. pseudintermedius (MRSP) infections have become increasingly common. For …
Transcriptional Regulation Of Azole Antifungal Resistance And Tolerance In Candida Glabrata, Kelly E. Caudle
Transcriptional Regulation Of Azole Antifungal Resistance And Tolerance In Candida Glabrata, Kelly E. Caudle
Theses and Dissertations (ETD)
Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including Candida species. In recent years, Candida glabrata has become the second most common cause of mucosal and invasive fungal infections in humans second to Candida albicans. Not only are systemic C. glabrata infections characterized by high mortality rates, treatment failures to the azole class of antifungals, the most widely used antifungal for treatment of Candida infections, have been reported. Contributing to this problem, C. glabrata exhibits intrinsic reduced susceptibility to the azole antifungals, and the development of high-level azole resistance …
Antibiotic Sensitivity Patterns Of Hospital-Acquired And Community-Acquired Methicillin Resistant Staphylococcus Aureus, Iyad Kaddora
Antibiotic Sensitivity Patterns Of Hospital-Acquired And Community-Acquired Methicillin Resistant Staphylococcus Aureus, Iyad Kaddora
Theses, Dissertations and Capstones
Staphylococcus aureus is one of the most dangerous human pathogens. An intensive effort to control resistant staphylococci, especially methicillin resistant Staphylococcus aureus (MRSA), is vital as it is the most common cause of hospitalacquired infections. During the one year study period, a total of 35 MRSA isolates were collected. Fifteen isolates were identified as hospital-acquired (HA) infections, and 20 isolates were determined to be community acquired (CA). All 15 (100%) HA-MRSA strains were resistant to clindamycin and to erythromycin. Thirteen isolates (87%) were resistant to ciprofloxacin and levofloxacin, and 12 (80%) were resistant to moxifloxacin. Of the 20 CA-MRSA isolates, …