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2007

Organisms

Theses, Dissertations and Capstones

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Investigation Of Environmental Microorganisms Associated With The Intrinsic Microbial Contamination Of An Alcohol-Free Mouthwash, Michelle D. Trickett Jan 2007

Investigation Of Environmental Microorganisms Associated With The Intrinsic Microbial Contamination Of An Alcohol-Free Mouthwash, Michelle D. Trickett

Theses, Dissertations and Capstones

The United States Pharmacopoeia (USP) Microbial Limits Test and Preservative Effectiveness Test were validated and completed on an alcohol-free mouthwash using standard USP recommended microorganisms and selected organisms isolated from the manufacturing environment. The microbial limits test using environmental isolates was found equivalent to the USP Microbial Limits Test currently used for release of the product. The preservative effectiveness test was performed to determine the efficacy of the parabens system against environmental isolates compared to those recommended in the USP test. In both tests Pseudomonas aeruginosa isolates exhibited resistance to the preservative system. All other isolates failed to grow after …