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Full-Text Articles in Organisms
The Noncanonical Roles Of Two Primordial Molecules In Flagella, Xiaoyan Zhu
The Noncanonical Roles Of Two Primordial Molecules In Flagella, Xiaoyan Zhu
Dissertations (1934 -)
Motile cilia and flagella are ancient organelles that eukaryotic organisms today still rely on to thrive in their natural environment. Not surprisingly, accumulated evidence has shown that the intricate motility machinery, the microtubule-based axoneme, is evolutionarily conserved down to the molecular level. This notion is epitomized by the signature axonemal complex, the radial spoke (RS). The RS is part of a control center conferring the high frequency and tightly regulated movement. Key RS proteins discovered in biflagellate green alga, Chlamydomonas reinhardtii, are also generated by nearly all ciliated organisms, including Homo sapiens. Among them are two subunits from primordial protein …
Rediscovery Of The Microtubule System In Chlamydomonas, Yi Liu
Rediscovery Of The Microtubule System In Chlamydomonas, Yi Liu
Dissertations (1934 -)
Extensive studies have revealed the complex mechanisms underlying the roles of the microtubule system in fundamental cellular processes, the severe consequences in development and health resulted from its anomaly, and the irreplaceable therapeutic agents that perturbs this vital yet inherently unstable cytoskeletal system. Most of the concepts derived from a handful of model organisms become dogma of the field despite contrary observations. By overcoming a major limitation of biflagellate green alga Chlamydomonas - the intense autofluorescence common to photosynthetic cells - this dissertation discovered new phenomena of the microtubule system and conceived an invention. The microtubule system of the green …