Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Animals (2)
- Life Sciences (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Animal Experimentation and Research (1)
-
- Behavior and Behavior Mechanisms (1)
- Behavioral Neurobiology (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Cell and Developmental Biology (1)
- Chemicals and Drugs (1)
- Developmental Biology (1)
- Developmental Neuroscience (1)
- Disease Modeling (1)
- Diseases (1)
- Enzymes and Coenzymes (1)
- Immunity (1)
- Immunology and Infectious Disease (1)
- Immunology of Infectious Disease (1)
- Investigative Techniques (1)
- Medical Anatomy (1)
- Medical Cell Biology (1)
- Medical Physiology (1)
- Medical Sciences (1)
- Microbiology (1)
- Molecular Biology (1)
- Molecular and Cellular Neuroscience (1)
- Musculoskeletal Diseases (1)
- Musculoskeletal System (1)
- Keyword
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Organisms
The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen Kw Wong
The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen Kw Wong
Undergraduate Student Research Internships Conference
Clinical and preclinical studies indicate prenatal cannabis exposure (PCE) pathologically affects fetal brain development and may increase vulnerability to neuropsychiatric disorders, including schizophrenia and mood/anxiety disorders. In review research from our lab suggests that fetal exposure to Δ9-THC sex-selectively impairs mesocorticolimbic (MCL) circuit function. However, there is a distinct lack of focus on PCE models on the BLA. The BLA plays a central role within the MCL where it directly interacts with the VTA, PFC and HIPP. Importantly, our model exhibits significant VTA hyperdopaminergic activity, and sex-specific alterations to PFC/HIPP glutamate firing, alongside region- and sex-specific changes in dopamine (DA), …
Rna Isolation In Duchenne Muscular Dystrophy (Dmd) Mice Models, Salem Abu Al-Burak
Rna Isolation In Duchenne Muscular Dystrophy (Dmd) Mice Models, Salem Abu Al-Burak
Undergraduate Student Research Internships Conference
Fibrosis is a progressive and typically irreversible disease process characterized by the excessive deposition of collagen in organs and in tissues of the musculoskeletal (MSK) system1,2. This process, which causes loss of organ and tissue function, can be initiated by micro-traumas3, an excessive and/or prolonged immune response1, the activation and proliferation of fibrosis-inducing progenitor cells4, and a pro-fibrotic extra-cellular microenvironment5. In parallel with the events that initiate fibrosis, genetic or environmental influences may cause cells and tissues to become predisposed to fibrosis development prior to initiation. This suggests that these …
Regulation Of Mhc Ii Trafficking And Expression By Host And Viral Factors, Alex Lac
Regulation Of Mhc Ii Trafficking And Expression By Host And Viral Factors, Alex Lac
Electronic Thesis and Dissertation Repository
Antigen presentation by major histocompatibility complex class II (MHC II) to the adaptive immune system is crucial for mounting sterilizing immune responses. This central role has made antigen presentation a target for antagonism by many pathogens. Notably, infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease MHC II expression in several immune cells. The mechanisms responsible for this suppression are unknown but involves either redirecting MHC II molecules away from the cell surface or inhibiting MHC II expression. To understand how pathogens manipulate intracellular MHC II trafficking, we first investigated the role of the Golgi trafficking regulator, ERC1, in …