Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Acid stress (1)
- Active-site model (1)
- Antibiotics (1)
- Bioinformatics (1)
- Biologics (1)
-
- Carbon catabolite repression (1)
- Cysteine protease (1)
- Enzyme kinetics (1)
- Infective endocarditis (1)
- Medicine (1)
- Metabolomics (1)
- N-terminal processing (1)
- Phage (1)
- Ribosomal protein L27 (1)
- Site-specific cleavage (1)
- Substrate specificity (1)
- Therapy (1)
- Transcriptomics (1)
- Translational medicine (1)
- Viral (1)
- Virus (1)
- ZIP family protein (1)
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Organisms
The Role Of Manganese In Streptococcus Sanguinis, Tanya M. Puccio
The Role Of Manganese In Streptococcus Sanguinis, Tanya M. Puccio
Theses and Dissertations
Streptococcus sanguinis is primarily associated with oral health as a commensal bacterium. As an opportunistic pathogen, S. sanguinis is capable of colonizing heart valve vegetations, leading to the disease infective endocarditis. Previous studies from our lab have identified the high-affinity manganese transporter SsaACB as important for endocarditis virulence. The impact that manganese depletion has on S. sanguinis had never been evaluated and a secondary manganese transporter has not been identified. Thus, we employed the use of a fermentor to control large-scale growth over time and depleted manganese in an ΔssaACB mutant using a metal chelator, EDTA. The changes in …
Characterization Of A Novel Protease In Staphylococcus Aureus, Adam L. Johnson
Characterization Of A Novel Protease In Staphylococcus Aureus, Adam L. Johnson
Theses and Dissertations
A newly discovered cysteine protease, Prp, has been shown to perform an essential, site-specific cleavage of ribosomal protein L27 in Staphylococcus aureus. In Firmicutes and related bacteria, ribosomal protein L27 is encoded with a conserved N-terminal extension that must be removed to expose residues critical for ribosome function. Uncleavable and pre-cleaved variants were unable to complement an L27 deletion in S. aureus, indicating that this N-terminal processing event is essential and likely plays an important regulatory role. The gene encoding the responsible protease (prp) has been shown to be essential, and is found in all organisms …
Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet
Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet
Undergraduate Research Posters
The World Health Organization has described the rise of antibiotic use as a “global heath security emergency” (who.int). With the growing concern about antibiotic resistant bacteria, there has been an increased interest in bacteriophages. Bacteriophages are high-specific viruses that only infect bacteria. The use of bacteriophages medicinally to treat bacteria is called phage therapy. Research in phage therapy gained momentum until the introduction of antibiotics. While the USA and other Western countries accepted antibiotics, the Soviet Union and their satellite nations still continued to research phages. Since the funding for research was supplied by the Soviet military, the results of …