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Investigation Of The Vesicular Stomatitis Virus Matrix Protein: Uncoating And Assembly, Chad E. Mire
Investigation Of The Vesicular Stomatitis Virus Matrix Protein: Uncoating And Assembly, Chad E. Mire
Theses and Dissertations (ETD)
Vesicular Stomatitis Virus (VSV) is a simple, enveloped, nonsegmented negative-strand RNA virus and is the prototype rhabdovirus to study viral entry, transcription, replication, and assembly. The matrix protein (M) of VSV is a central component of the viral replication cycle. While being the smallest of the viral proteins it is multifunctional and is involved in uncoating, cytopathic effects (CPE), and assembly of the virus. M protein interactions involved in the uncoating and assembly of VSV have been examined in this dissertation.
Uncoating of VSV involves dissociation of M from the ribonucleoprotein core (RNPs) of the virus. Current models of VSV …