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Articles 1 - 2 of 2
Full-Text Articles in Organisms
Investigating Alternative Induction Of The S. Aureus 80a Prophage, Jody Caretti
Investigating Alternative Induction Of The S. Aureus 80a Prophage, Jody Caretti
Student Scholar Showcase
Widespread antibiotic resistance has quickly become one of the most concerning crises affecting modern medicine, especially in cases of Staphylococcal infections, which have become resistant to all ��-lactam antibiotics. As a result, research into alternative forms of treatment for bacterial infections is a top priority. Bacteriophage therapy is a popular candidate for replacing antibiotics, due to the way the viruses interact with the bacteria. The 80�� prophage integrates its DNA into Staphylococcus aureus strain 10616 via the lysogenic cycle, and replicates with the bacterial cell. When stressed, the bacteria stop replicating and the prophage stimulates the lytic cycle, activating transcription …
Downstream Pathway Activation In Cultured Hepatocytes Following Treatment With Francisella Tularensis, Nicole Wakefield
Downstream Pathway Activation In Cultured Hepatocytes Following Treatment With Francisella Tularensis, Nicole Wakefield
Undergraduate Theses and Capstone Projects
Francisella tularensis, the intracellular pathogen that causes tularemia, was investigated to determine how it infects and replicates within mammalian hepatocytes. To date, it has been shown that hepatocytes can be infected by F. tularensis and that this causes considerable change in the protein phosphorylation state of several vital signaling molecules within the host cell. Protein kinase pathways can be mapped as signatures of infection. Hepatocytes tend to be susceptible to infection by F. tularensis, thus stimulating internal signaling. The Francisella strains used were selected with the goal of producing a model that can be used to elucidate the cell signaling …