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Sera Of Iga Nephropathy Patients Contain A Heterogeneous Population Of Relatively Cationic Alpha-Heavy Chains, Onn Haji Hashim
Sera Of Iga Nephropathy Patients Contain A Heterogeneous Population Of Relatively Cationic Alpha-Heavy Chains, Onn Haji Hashim
Onn Haji Hashim
Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings …