Open Access. Powered by Scholars. Published by Universities.®

Organisms Commons

Open Access. Powered by Scholars. Published by Universities.®

Systems Biology

2020

Articles 1 - 1 of 1

Full-Text Articles in Organisms

The Role Of Manganese In Streptococcus Sanguinis, Tanya M. Puccio Jan 2020

The Role Of Manganese In Streptococcus Sanguinis, Tanya M. Puccio

Theses and Dissertations

Streptococcus sanguinis is primarily associated with oral health as a commensal bacterium. As an opportunistic pathogen, S. sanguinis is capable of colonizing heart valve vegetations, leading to the disease infective endocarditis. Previous studies from our lab have identified the high-affinity manganese transporter SsaACB as important for endocarditis virulence. The impact that manganese depletion has on S. sanguinis had never been evaluated and a secondary manganese transporter has not been identified. Thus, we employed the use of a fermentor to control large-scale growth over time and depleted manganese in an ΔssaACB mutant using a metal chelator, EDTA. The changes in …