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Sustained Adrenergic Signaling Promotes Cervical Cancer Progression, Nouara C. Sadaoui
Sustained Adrenergic Signaling Promotes Cervical Cancer Progression, Nouara C. Sadaoui
Dissertations & Theses (Open Access)
Background: Chronic stress and sustained adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of HPV oncogenes, E6 and E7.
Materials and Methods: ADRβ expression levels were examined in patient-derived cervical cancer samples. We used an orthotopic model of cervical cancer to investigate the effects of restraint stress on tumor growth and metastasis. We evaluated the in vivo effects of a β-blocker, propranolol, and HPV E6/E7 siRNA. In vitro, ADRβ positive cervical cancer cells were …