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Maternal, Child Health and Neonatal Nursing Commons™
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- Discipline
- Keyword
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- Pregnancy (11)
- Breastfeeding (3)
- Caesarean section (3)
- Meta-analysis (3)
- Neonate (3)
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- Preterm birth (3)
- Child development (2)
- Childbirth (2)
- Children (2)
- Community child health (2)
- Diabetes (2)
- Early intervention (2)
- Health facilities (2)
- Hypertension (2)
- Infant-mother interaction (2)
- Inflammation (2)
- Lactation (2)
- Low birth weight infant (2)
- Low- and middle-income countries (2)
- Maternal and child health (2)
- Maternal diet (2)
- Maternal-child health (2)
- Mental health (2)
- Obesity (2)
- Offspring (2)
- Overweight (2)
- Preeclampsia (2)
- Probiotics (2)
- Randomized controlled trial (2)
- Space requirements (2)
Articles 1 - 30 of 46
Full-Text Articles in Maternal, Child Health and Neonatal Nursing
The Impact Of Hypertensive Disorders Of Pregnancy On Cognitive Outcomes In Offspring: Systematic Review And Meta-Analysis, Berihun Dachew, Tusa, Getinet Ayano, Kim Betts, Amanuel Gebremedhin, Daniel Rudaizky, Gizachew A. Tessema, Rosa Alati
The Impact Of Hypertensive Disorders Of Pregnancy On Cognitive Outcomes In Offspring: Systematic Review And Meta-Analysis, Berihun Dachew, Tusa, Getinet Ayano, Kim Betts, Amanuel Gebremedhin, Daniel Rudaizky, Gizachew A. Tessema, Rosa Alati
Research outputs 2022 to 2026
Purpose To synthesis the available research on the association between hypertensive disorders during pregnancy (HDP) and adverse cognitive outcomes in children. Methods PubMed, MEDLINE, Embase, Scopus, CINAHL, and PsycInfo were searched from inception to February 2026 to identify relevant studies. Effect estimates and 95% confidence intervals (CIs) were extracted and pooled using inverse variance–weighted random-effects meta-analysis. Results Thirty-nine observational studies published between 1982 and 2026, covering over 12.5 million mother-offspring pairs, were included in the final analysis. The findings indicate that HDP were associated with a 39% increased risk of Intellectual Disability (ID) (OR = 1.39, 95% CI = 1.30–1.47) …
Impacts Of The Early Collaborative Intervention On Mother-Preterm Infant Interaction At One Month Of Age: Secondary Analysis Of A Randomized Controlled Trial, Charlotte Sahlén Helmer, Ulrika Birberg Thornberg, Thomas Abrahamsson, Evalotte Mörelius
Impacts Of The Early Collaborative Intervention On Mother-Preterm Infant Interaction At One Month Of Age: Secondary Analysis Of A Randomized Controlled Trial, Charlotte Sahlén Helmer, Ulrika Birberg Thornberg, Thomas Abrahamsson, Evalotte Mörelius
Research outputs 2022 to 2026
Background A sensitive, well-functioning maternal interaction is vital for healthy infant development. For moderate to late preterm infants, this is even more important as this group of infants are at increased risk of facing neurodevelopmental disorders. The Early Collaborative Intervention supports parent-preterm infant interaction and includes three sessions, two in the hospital and one after discharge. Objective To investigate the impact of the Early Collaborative Intervention, compared with standard care, on mother-preterm infant interaction at one month corrected age. Design A longitudinal randomized controlled trial, reporting secondary outcomes from the first follow-up. Setting The intervention was conducted at a pediatric …
Immediate Skin-To-Skin Contact At Very Preterm Birth And Effect On Infant Socio-Emotional Stress Response And Mother–Infant Cortisol Co-Regulation: Secondary Outcomes From The Randomised Clinical Immediate Parent-Infant Skin-To-Skin Study (Ipistoss), Karoline Lode-Kolz, Siri Lillieskold, Hanne Brit Hetland, Eleonora Mascheroni, Stina Klemming, Hanne Pike, Agnes Linner, Nils J. Bergman, Bjorn Westrup, Ulrika Ådén, Evalotte Morelius, Rosario Montirosso, Wibke Jonas, Siren Rettedal
Immediate Skin-To-Skin Contact At Very Preterm Birth And Effect On Infant Socio-Emotional Stress Response And Mother–Infant Cortisol Co-Regulation: Secondary Outcomes From The Randomised Clinical Immediate Parent-Infant Skin-To-Skin Study (Ipistoss), Karoline Lode-Kolz, Siri Lillieskold, Hanne Brit Hetland, Eleonora Mascheroni, Stina Klemming, Hanne Pike, Agnes Linner, Nils J. Bergman, Bjorn Westrup, Ulrika Ådén, Evalotte Morelius, Rosario Montirosso, Wibke Jonas, Siren Rettedal
Research outputs 2022 to 2026
Objective To explore the effects of immediate parent–infant skin-to-skin contact (iSSC) at very preterm birth on maternal–infant behavioural responses and hypothalamic–pituitary–adrenal (HPA) axis reactivity to age-appropriate socio-emotional stress at 4months corrected age. Design Two secondary outcomes from a multicentre randomised controlled trial with two non-blinded parallel groups. Setting Three Scandinavian neonatal intensive care units, level 2 and level 3. Participants 91 infants born at gestational age 28+0to 32+6 from April 2018 to June 2021. Singletons and twins with a second caregiver present were included, regardless of mode of birth. Higher-order births, infants with congenital infections and major malformations were excluded. …
Optimising Vaginal Microbiome Profiling For Clinical Translation: A Comparative Assessment Of Sample Storage Methods And A Vagina-Specific 16s Rrna Gene Database, Alishum Ali, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Morten E. Allentoft, Michael Bunce, Claus T. Christophersen
Optimising Vaginal Microbiome Profiling For Clinical Translation: A Comparative Assessment Of Sample Storage Methods And A Vagina-Specific 16s Rrna Gene Database, Alishum Ali, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Morten E. Allentoft, Michael Bunce, Claus T. Christophersen
Research outputs 2022 to 2026
Vaginal microbiome composition has been linked to risk of preterm birth (PTB), a persistent global health challenge. 16S rRNA microbial profiling has identified specific vaginal community state types (CSTs) that have been associated with PTB risk. Diagnostic profiling requires standardised pre-analytical protocols. We evaluated two storage methods and validated a curated, vagina-specific 16S rRNA gene database (VagDB) to enhance annotation. Paired Copan FLOQ swabs from 22 women at high PTB risk were processed for either (a) dry/immediate freezing or (b) Amies-stabilisation/refrigeration. Amplicon sequence variants were generated via 16S rRNA gene (V4) PCR and Illumina sequencing. We assessed diversity, composition, and …
Risk Factors Associated With Delayed Secretory Activation In A Cohort Of Nulliparous Women In Western Australia, Cassandra Cuffe, Giglia, Julie Hill, Matthew N. Cooper, Anita M. Moorhead, Joshua R. Lewis, Deborah Ireson, Therese A. O’Sullivan
Risk Factors Associated With Delayed Secretory Activation In A Cohort Of Nulliparous Women In Western Australia, Cassandra Cuffe, Giglia, Julie Hill, Matthew N. Cooper, Anita M. Moorhead, Joshua R. Lewis, Deborah Ireson, Therese A. O’Sullivan
Research outputs 2022 to 2026
Background: Delayed secretory activation can negatively impact maternal and child health through increasing the risk of early cessation of breastfeeding. Early cessation of breastfeeding is known to be associated with increased health risks. Aim: To determine the occurrence of, and risk factors associated with, delayed secretory activation in nulliparous women in Western Australia. Methods: This analysis used a subset of participants (n = 183) enrolled in a multicentre trial. Nulliparous low-risk pregnant women were enrolled between 28–32 weeks’ gestation and followed until 1 week after birth. The association between self-reported delayed secretory activation status (onset 4 days or more postpartum) …
Paternal Age Is Associated With Offspring Bone Health—But Not Soft Tissue Composition Or Fracture: The Vitamin D In Pregnancy Study, Mia A. Percival, Kara B. Anderson, Julie A. Pasco, Marc Sim, Sarah M. Hosking, John D. Wark, Natalie K. Hyde
Paternal Age Is Associated With Offspring Bone Health—But Not Soft Tissue Composition Or Fracture: The Vitamin D In Pregnancy Study, Mia A. Percival, Kara B. Anderson, Julie A. Pasco, Marc Sim, Sarah M. Hosking, John D. Wark, Natalie K. Hyde
Research outputs 2022 to 2026
Summary: Emerging evidence suggests that paternal health may be associated with offspring later life heath. In this study, advanced paternal age at childbirth was associated with poorer offspring bone mineral density and content at age 11 years. These findings suggest that paternal age may impact childhood musculoskeletal development, warranting further investigation. Introduction: Maternal health during pregnancy is known to impact offspring’s later life health. However, emerging evidence suggests that paternal factors may also be important. Advanced paternal age is associated with poorer offspring outcomes, yet few studies assess musculoskeletal outcomes. This study investigated the association between paternal age at childbirth …
Longitudinal Associations Between Maternal And Child Screen Use At 1 Year Of Age And Child Behavior And Development At 3 Years Of Age, Stephanie Sim, Juliana Zabatiero, Natasha Bear, Amber Beynon, George Thomas, Ravisha Srinivasjois, Brad Jongeling, Desiree Silva, Leon Straker
Longitudinal Associations Between Maternal And Child Screen Use At 1 Year Of Age And Child Behavior And Development At 3 Years Of Age, Stephanie Sim, Juliana Zabatiero, Natasha Bear, Amber Beynon, George Thomas, Ravisha Srinivasjois, Brad Jongeling, Desiree Silva, Leon Straker
Research outputs 2022 to 2026
Background: Young children are increasingly exposed to evolving screen technology. International guidelines recommend no screen use for children under the age of 2 years, due to the potential for detrimental effects on behaviour and development. However, evidence for these guidelines is limited by inadequate consideration of device-specific effects (TV and mobile phone/tablet computer), maternal screen use, confounders such as maternal mental health and importance of effect sizes. Our aim was to investigate longitudinal associations of device-specific maternal and child technology use and covariates (including maternal mental health) with behavioural and developmental outcomes, to guide adults on screen use behaviours by …
Norms For Scaling Up Small And Sick Newborn Care: An Overview Of Reviews, Natalie A. Strobel, Georgia Whisson, Derek Swe, Amy Budrikis, Karen M. Edmond
Norms For Scaling Up Small And Sick Newborn Care: An Overview Of Reviews, Natalie A. Strobel, Georgia Whisson, Derek Swe, Amy Budrikis, Karen M. Edmond
Research outputs 2022 to 2026
Background: The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) currently have no benchmarks or 'norms' for scaling up small and sick newborn (SSN) service delivery in health facilities in low- and middle-income countries (LMICs). Our objective was to understand which systematic reviews had addressed the following norms in the last five years: number of SSN beds per live births in a district or similar administrative unit (admission beds); space requirements for SSN units, including mother-infant dyads (space); health workforce ratios in SSN units (workforce); and travel time to health facilities with SSN units (travel time). Methods: …
Outcomes Following A Behaviour Change Intervention Within Hospitals To Improve Birth Registrations And Hospital Utilisation For Aboriginal And/Or Torres Strait Islander Infants: A Quasi-Experimental And Cohort Study, K. Mcauley, Natalie Ann Strobel, Daniel Christensen, Karen Margaret Edmond, Peter Jacoby, Daniel Mcaullay
Outcomes Following A Behaviour Change Intervention Within Hospitals To Improve Birth Registrations And Hospital Utilisation For Aboriginal And/Or Torres Strait Islander Infants: A Quasi-Experimental And Cohort Study, K. Mcauley, Natalie Ann Strobel, Daniel Christensen, Karen Margaret Edmond, Peter Jacoby, Daniel Mcaullay
Research outputs 2022 to 2026
Objectives The primary objective was to determine whether a behaviour change intervention delivered to hospital staff would (1) improve the proportion of Aboriginal and/or Torres Strait Islander (Aboriginal) babies being registered and (2) reduce hospital admissions and emergency presentations for babies <6 months old. The secondary objective was an observational analysis to determine factors that might influence the proportion of registered Aboriginal births in Western Australia (WA). Design Quasi-experimental design and cohort study. Setting Five tertiary birthing hospitals in WA. Participants The intervention was delivered to health service providers who were in the five tertiary birthing hospitals. Outcome data were collected on Aboriginal babies born between 1 January 2016 and 30 June 2018 who were delivered within these hospitals. Babies in the control group (n=226) were born 6months before the intervention and intervention babies (n=232) were born 6months following the intervention. For the secondary objective, there were 4573 babies included in the analysis. Interventions A behaviour change intervention delivered to hospital staff in five hospitals. Primary and secondary outcome measures The primary outcomes were the proportion of babies who were registered and whether a baby had been admitted to hospital or an emergency department by 3 and 6 months old. The secondary outcome was to determine factors that might influence the proportion of registered Aboriginal births in WA (cohort study). Results There was evidence of a 38% reduction in emergency presentations within 6months for babies born to hospitals 6months following the staff training (OR 0.62, 95%CI 0.42 to 0.91), and little evidence of improvements in birth registrations, hospital admissions within 3 or 6months of birth or emergency department presentations within 3months of birth. Of the 4573 babies included in the cohort study, 3769 (82.4%) babies had their births registered and 804 (17.6%) babies did not. Factors that were associated with not having a birth registered included low birth weight babies with a 34% decrease in odds of having a registered birth compared with those with a normal birth weight (adjusted OR (aOR) 0.66, 95%CI 0.51 to 0.86). Timing of first antenatal visit was associated with reduced odds of having a birth registered if this occurred in the second (aOR 0.77, 95%CI 0.64 to 0.93) or third trimester (aOR 0.59, 95%CI 0.45 to 0.77) compared with the first trimester. Conclusions Our study identifies the complexities surrounding birth registrations and improved hospital utilisation for Aboriginal babies, the importance of targeted interventions and ongoing efforts needed to address this issue comprehensively.
Skin-To-Skin Contact At Birth For Very Preterm Infants And Symptoms Of Depression And Anxiety In Parents During The First Year – A Secondary Outcome Of A Randomized Clinical Trial, Siri Lilliesköld, Karoline Lode-Kolz, Björn Westrup, Nils Bergman, Kimmo Sorjonen, Ulrika Ådén, Evalotte Mörelius, Siren Rettedal, Wibke Jonas
Skin-To-Skin Contact At Birth For Very Preterm Infants And Symptoms Of Depression And Anxiety In Parents During The First Year – A Secondary Outcome Of A Randomized Clinical Trial, Siri Lilliesköld, Karoline Lode-Kolz, Björn Westrup, Nils Bergman, Kimmo Sorjonen, Ulrika Ådén, Evalotte Mörelius, Siren Rettedal, Wibke Jonas
Research outputs 2022 to 2026
Background: Mental health issues are common in parents to preterm infants. In the neonatal intensive care unit (NICU), skin-to-skin contact (SSC) as an avenue for parent-infant closeness may improve parental mental health. Few studies exist regarding its benefits when initiated immediately postbirth. The aim was to determine the effect of SSC for very preterm infants at birth on parents' mental health, by assessing symptoms of depression and anxiety within the first year. Methods: The Immediate Parent-Infant Skin-to-Skin Study was a randomized clinical trial conducted 2018–2021 at three NICUs in Sweden and Norway. Very preterm infants (28–33 weeks of gestation) were …
Management Of Neonates In The Special Care Nursery And Its Impact On The Developing Gut Microbiota: A Comprehensive Clinical Review, Ravisha Srinivasjois, Shripada Rao, Gavin Pereira
Management Of Neonates In The Special Care Nursery And Its Impact On The Developing Gut Microbiota: A Comprehensive Clinical Review, Ravisha Srinivasjois, Shripada Rao, Gavin Pereira
Research outputs 2022 to 2026
The first few days following the birth are a vulnerable time for the neonate. Sick infants experience various interventions during their stay in the neonatal unit in order to stay alive and grow. Acquisition of gut microbes is critical for the short- and long-term health of the neonate. At a time when the gut microbiome is starting to take shape, crucial interventions directed at improving the growth, development and survival of the neonate impact its development. Events prior to and after the birth of the neonate, such as maternal conditions, antibiotic exposure, type of feeds, supplemental probiotics, and neonatal intensive …
Determining Space Requirements For Small And Sick Newborns And Their Mothers In Health Facilities: A Systematic Review, Natalie Strobel, Georgia Whisson, Derek Swe, Rajesh Mehta, Amy Budrikis, Karen Edmond
Determining Space Requirements For Small And Sick Newborns And Their Mothers In Health Facilities: A Systematic Review, Natalie Strobel, Georgia Whisson, Derek Swe, Rajesh Mehta, Amy Budrikis, Karen Edmond
Research outputs 2022 to 2026
Background There are currently no World Health Organization and United Nations Children Fund benchmarks or ‘norms’ for scaling up small and sick newborn (SSN) service delivery in health facilities in low- and middle-income countries (LMICs). Specifically, there is limited evidence on optimal bed space requirements in SSN units such as special care nurseries and neonatal intensive care units (NICUs). Through this systematic review, we aimed to gather evidence on the optimal space requirements needed for SSNs and their mothers in health facilities, particularly at level 2 district hospitals. Methods We included simulation, experimental, and observational studies, as well as guidelines …
Moderate-To-Late Preterm Infants Benefit From The Early Collaborative Intervention: Primary Outcomes Of An Rct, Ulrika Birberg Thornberg, Felix Sebastian Koch, Charlotte Sahlén Helmer, Jonna Tell, Ellinore Nyberg, Thomas Abrahamsson, Evalotte Mörelius
Moderate-To-Late Preterm Infants Benefit From The Early Collaborative Intervention: Primary Outcomes Of An Rct, Ulrika Birberg Thornberg, Felix Sebastian Koch, Charlotte Sahlén Helmer, Jonna Tell, Ellinore Nyberg, Thomas Abrahamsson, Evalotte Mörelius
Research outputs 2022 to 2026
Aim: This study aimed to determine the longitudinal impact of the EArly Collaborative Intervention (EACI), a three-session early intervention designed to enhance parent-infant interaction, on the developmental outcomes of preterm infants born between 30 + 0 and 35 + 6 weeks of gestation. Methods: This randomised controlled blinded study recruited families in two neonatal intensive care units in Sweden. In this one-year follow-up, 87 infants (standard care = 37, standard care with EACI = 50) were included in the intention-to-treat analysis. The primary study outcomes were cognition, receptive and expressive communication, and fine and gross motor development measured with the …
Determinants Of Short Interpregnancy Intervals In High-Income Countries: A Systematic Review, J. Dunne, D. Foo, J. Jancey, G. Pereira, B. Kefale, D. G. Belay, G. Dhamrait, A. T. Gebremedhin, K. B. Mruts, S. D. Nyadanu, A. Roy, G. A. Tessema
Determinants Of Short Interpregnancy Intervals In High-Income Countries: A Systematic Review, J. Dunne, D. Foo, J. Jancey, G. Pereira, B. Kefale, D. G. Belay, G. Dhamrait, A. T. Gebremedhin, K. B. Mruts, S. D. Nyadanu, A. Roy, G. A. Tessema
Research outputs 2022 to 2026
Short interpregnancy intervals (IPIs) of <6–18 months are associated with adverse maternal and child outcomes. This study aimed to identify the individual, relationship, community, and societal factors that influence short IPIs in high-income countries. A comprehensive search was undertaken in CINAHL Plus, Ovid/EMBASE, Ovid/MEDLINE, Ovid/PsycINFO, ProQuest, PubMed, Scopus, Web of Science, and Google Scholar for articles published in English from 1st January 1990 to 26th October 2023. Studies were included if they reported an effect estimate of at least one determinant of pregnancy spacing in a high-income country. The quality of the included studies was assessed using the Johanna Briggs Institute Critical Appraisal Tool and Cochrane Risk Assessment Tool. Multi-level factors at the individual, relationship, community, and societal level were systematically identified through the socio-ecological model. This study is registered with PROSPERO (CRD42020176311). Of 2005 unique articles, 220 were identified for full-text review, and 55 met the inclusion criteria representing a total of 27,103,055 women from 13 high-income countries. All the included studies were deemed to be of moderate to high quality. Most of the studies reported determinants of short IPI at the individual level, with non-use of contraception the most common reported factor. Peer influence was a factor at the relationship level, and access to health care and reproductive services were impactful at the community and societal levels, respectively. Future research and efforts should support the development and implementation of policies and practices that support optimum pregnancy spacing from a comprehensive socio-ecological position.
Estimating The Number Of Hospital Beds For The Care Of Sick And Small Newborns: An Evidence-Based Systematic Approach, Bireshwar Sinha, Mohan Kumar, Deena Thomas, Natalie Strobel, Gagan Gupta, Karen Edmond, M. Jeeva Sankar
Estimating The Number Of Hospital Beds For The Care Of Sick And Small Newborns: An Evidence-Based Systematic Approach, Bireshwar Sinha, Mohan Kumar, Deena Thomas, Natalie Strobel, Gagan Gupta, Karen Edmond, M. Jeeva Sankar
Research outputs 2022 to 2026
Background Current recommendations for neonatal bed requirements are largely assumption-based rather than data-driven. We aimed to estimate the number of beds per 1000 live births needed for the care of small and sick newborns. Methods We first extracted data from studies published between 2018 and May 2023. Then, due to considerable heterogeneity in the data, we performed a meta-analysis using a random effects model to estimate the number of neonatal admissions and the length of stay. We divided the total patient days (admission rate multiplied by the length of stay) by 365 to estimate the annual number of beds per …
Of Scents And Cytokines: How Olfactory And Food Aversions Relate To Nausea And Immunomodulation In Early Pregnancy, Dayoon Kwon, Daniel M.T. Fessler, Delaney A. Knorr, Kyle S. Wiley, Julie Sartori, David A. Coall, Molly M. Fox
Of Scents And Cytokines: How Olfactory And Food Aversions Relate To Nausea And Immunomodulation In Early Pregnancy, Dayoon Kwon, Daniel M.T. Fessler, Delaney A. Knorr, Kyle S. Wiley, Julie Sartori, David A. Coall, Molly M. Fox
Research outputs 2022 to 2026
Background: During pregnancy, the maternal body undergoes extensive physiological adaptations to support embryonic growth, including whole-body remodeling, that may induce odor and food aversions, as well as nausea and vomiting. The biological mechanisms behind odor and food aversions, as well as nausea and vomiting in early pregnancy, remain largely unexplored. Our study investigated associations between these changes and cytokine profiles during pregnancy. Methodology: A cohort of pregnant Latina women in Southern California (n = 58) completed a structured questionnaire on pregnancy "morning sickness"-related symptoms and aversions. Maternal plasma cytokine levels were measured between 5 and 17 weeks' gestation. Results: About …
Effects Of Pregnancy And Lactation Prebiotics Supplementation On Infant Allergic Disease: A Randomized Controlled Trial, Debra J. Palmer, Alana R. Cuthbert, Thomas R. Sullivan, Rachelle A. Pretorius, Johan Garssen, Kristina Rueter, Maria C. Jenmalm, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott
Effects Of Pregnancy And Lactation Prebiotics Supplementation On Infant Allergic Disease: A Randomized Controlled Trial, Debra J. Palmer, Alana R. Cuthbert, Thomas R. Sullivan, Rachelle A. Pretorius, Johan Garssen, Kristina Rueter, Maria C. Jenmalm, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott
Research outputs 2022 to 2026
Background: Ingestion of prebiotics during pregnancy and lactation may have immunomodulatory benefits for the developing fetal and infant immune system and provide a potential dietary strategy to reduce the risk of allergic diseases. Objective: We sought to determine whether maternal supplementation with dietary prebiotics reduces the risk of allergic outcomes in infants with hereditary risk. Methods: We undertook a double-blind randomized controlled trial in which pregnant women were allocated to consume prebiotics (14.2 g daily of galacto-oligosaccharides and fructo-oligosaccharides in the ratio 9:1) or placebo (8.7 g daily of maltodextrin) powder from less than 21 weeks’ gestation until 6 months …
Caesarean Section And Associated Factors In Nigeria: Assessing Inequalities Between Rural And Urban Areas—Insights From The Nigeria Demographic And Health Survey 2018, Emmanuel O. Adewuyi, Wole Akosile, Victory Olutuase, Aaron Akpu Philip, Rhoda Olaleru, Mary I. Adewuyi, Asa Auta, Vishnu Khanal
Caesarean Section And Associated Factors In Nigeria: Assessing Inequalities Between Rural And Urban Areas—Insights From The Nigeria Demographic And Health Survey 2018, Emmanuel O. Adewuyi, Wole Akosile, Victory Olutuase, Aaron Akpu Philip, Rhoda Olaleru, Mary I. Adewuyi, Asa Auta, Vishnu Khanal
Research outputs 2022 to 2026
Introduction: When medically indicated, caesarean section (CS) can be a life-saving intervention for mothers and their newborns. This study assesses the prevalence of CS and its associated factors, focussing on inequalities between rural and urban areas in Nigeria. Methods: We disaggregated the Nigeria Demographic and Health Survey 2018 and performed analyses separately for Nigeria’s overall, rural, and urban residences. We summarised data using frequency tabulations and identified factors associated with CS through multivariable logistic regression analysis. Results: CS prevalence was 2.7% in Nigeria (overall), 5.2% in urban and 1.2% in rural areas. The North-West region had the lowest prevalence of …
Impact Of Healthy Pregnancy And Lifestyle In Mothers On Developmental Delay In Their Offspring: A Strength-Based Analysis Of A Longitudinal Study Among Indigenous Children In Australia, Md Irteja Islam, Thomas Stubbs, Tuguy Esgin, Alexandra Martiniuk
Impact Of Healthy Pregnancy And Lifestyle In Mothers On Developmental Delay In Their Offspring: A Strength-Based Analysis Of A Longitudinal Study Among Indigenous Children In Australia, Md Irteja Islam, Thomas Stubbs, Tuguy Esgin, Alexandra Martiniuk
Research outputs 2022 to 2026
Introduction: Extensive literature has investigated the prenatal risk factors of developmental delay in children, with evidence highlighting the impact of prenatal health, mental health, and behavioural factors. While a deficit discourse has underscored Indigenous health research and policies, strengths-based approaches provide an opportunity to reframe this discourse, to illustrate and celebrate the strength and resilience of Australian Indigenous families. As such, this study aimed to identify the protective impact of healthy pregnancy and lifestyle in mothers on developmental delay in Indigenous Australian children; and whether it varies by child birthweight adjusted for gestational age. Further, we also tested whether child …
Associations Between Maternal Preconception And Pregnancy Adiposity And Neuropsychiatric And Behavioral Outcomes In The Offspring: A Systematic Review And Meta-Analysis, Bereket Duko, Tesfaye S. Mengistu, David Stacey, Lisa J. Moran, Gizachew Tessema, Gavin Pereira, Asres Bedaso, Amanuel Tesfay Gebremedhin, Rosa Alati, Oyekoya T. Ayonrinde, Beben Benyamin, S. Hong Lee, Elina Hyppönen
Associations Between Maternal Preconception And Pregnancy Adiposity And Neuropsychiatric And Behavioral Outcomes In The Offspring: A Systematic Review And Meta-Analysis, Bereket Duko, Tesfaye S. Mengistu, David Stacey, Lisa J. Moran, Gizachew Tessema, Gavin Pereira, Asres Bedaso, Amanuel Tesfay Gebremedhin, Rosa Alati, Oyekoya T. Ayonrinde, Beben Benyamin, S. Hong Lee, Elina Hyppönen
Research outputs 2022 to 2026
Maternal adiposity (overweight or obesity) has been associated with adverse perinatal outcomes, although the potential risks of long-term neuropsychiatric and behavioral outcomes in the offspring remain unclear. Using the PRISMA guidelines, we searched PubMed, EMBASE, Scopus, and Web of Science to identify studies on maternal adiposity and offspring neuropsychiatric outcomes. Inverse variance-weighted random-effects meta-analyses were used to pool effect estimates with 95 % confidence intervals (95 % CIs) from adjusted odds ratios (OR) and hazard ratios (HR). Estimates were computed separately for preconception and pregnancy maternal overweight and obesity, with outcomes stratified by the type of neuropsychiatric outcome. In our …
Global Management Of Serious Bacterial Infections In Young Infants Aged 0 To 59 Days: An Overview Of Systematic Reviews, Karen M. Edmond, Georgia R. Whisson, Derek C. Swe, Natalie A. Strobel
Global Management Of Serious Bacterial Infections In Young Infants Aged 0 To 59 Days: An Overview Of Systematic Reviews, Karen M. Edmond, Georgia R. Whisson, Derek C. Swe, Natalie A. Strobel
Research outputs 2022 to 2026
BACKGROUND: To inform World Health Organization guidelines for the management of serious bacterial infection (SBI) (suspected or confirmed sepsis, pneumonia, or meningitis) in infants aged 0–59 days. OBJECTIVE: To conduct an “overview of systematic reviews” to: (1) understand which systematic reviews have examined diagnosis and management of SBI in infants aged 0–59 days in the last 5 years; and (2) assess if the reviews examined PICOs (population, intervention, comparator, outcomes) and regimens currently being recommended in low and middle income countries (LMICs) by the World Health Organization. DATA SOURCES: MEDLINE; Embase; Cochrane Library; Epistemonikos; PROSPERO. STUDY SELECTION: Systematic reviews of …
Abnormal Cleavage Up To Day 3 Does Not Compromise Live Birth And Neonatal Outcomes Of Embryos That Have Achieved Full Blastulation: A Retrospective Cohort Study, Tammy Lee, Kelli Peirce, Jay Natalwala, Vincent Chapple, Peter J. Mark, Katherine Sanders, Yanhe Liu
Abnormal Cleavage Up To Day 3 Does Not Compromise Live Birth And Neonatal Outcomes Of Embryos That Have Achieved Full Blastulation: A Retrospective Cohort Study, Tammy Lee, Kelli Peirce, Jay Natalwala, Vincent Chapple, Peter J. Mark, Katherine Sanders, Yanhe Liu
Research outputs 2022 to 2026
STUDY QUESTION: Do embryos displaying abnormal cleavage (ABNCL) up to Day 3 have compromised live birth rates and neonatal outcomes if full blastulation has been achieved prior to transfer? SUMMARY ANSWER: ABNCL is associated with reduced full blastulation rates but does not impact live birth rates and neonatal outcomes once full blastulation has been achieved. WHAT IS KNOWN ALREADY?: It is widely accepted that ABNCL is associated with reduced implantation rates of embryos when transferred at the cleavage stage. However, evidence is scarce in the literature reporting birth outcomes from blastocysts arising from ABNCL embryos, likely because they are ranked …
Diabetic And Hypertensive Disorders Following Early Pregnancy Loss: A Systematic Review And Meta-Analysis, Jennifer Dunne, Damien Foo, Berihun A. Dachew, Bereket Duko, Amanuel T. Gebremedhin, Sylvester D. Nyadanu, Gavin Pereira, Gizachew A. Tessema
Diabetic And Hypertensive Disorders Following Early Pregnancy Loss: A Systematic Review And Meta-Analysis, Jennifer Dunne, Damien Foo, Berihun A. Dachew, Bereket Duko, Amanuel T. Gebremedhin, Sylvester D. Nyadanu, Gavin Pereira, Gizachew A. Tessema
Research outputs 2022 to 2026
Background: Spontaneous and induced abortions are common outcomes of pregnancy. There is inconsistent evidence of an association between early pregnancy loss and subsequent diabetic and hypertensive disorders in women. This systematic review and meta-analysis evaluated evidence on the risk of the subsequent development of pregnancy and non-pregnancy related diabetic and hypertensive disorders in women who experienced an early pregnancy loss. Methods: Systematic searches were conducted in seven electronic databases (CINAHL Plus, Ovid/EMBASE, Ovid/MEDLINE, ProQuest, PubMed, Scopus, and Web of Science) from inception to 22nd December 2023. Studies were included if they reported an exposure of spontaneous abortion (SAB), induced abortion …
Maternal Prebiotic Supplementation During Pregnancy And Lactation Modifies The Microbiome And Short Chain Fatty Acid Profile Of Both Mother And Infant, Jacquelyn M. Jones, Stacey N. Reinke, Mahsa Mousavi-Derazmahalleh, Johan Garssen, Maria C. Jenmalm, Ravisha Srinivasjois, Desiree Silva, Jeffrey Keelan, Susan L. Prescott, Debra J. Palmer, Claus T. Christophersen
Maternal Prebiotic Supplementation During Pregnancy And Lactation Modifies The Microbiome And Short Chain Fatty Acid Profile Of Both Mother And Infant, Jacquelyn M. Jones, Stacey N. Reinke, Mahsa Mousavi-Derazmahalleh, Johan Garssen, Maria C. Jenmalm, Ravisha Srinivasjois, Desiree Silva, Jeffrey Keelan, Susan L. Prescott, Debra J. Palmer, Claus T. Christophersen
Research outputs 2022 to 2026
Background & aims: Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from < 21 weeks' gestation to six months’ post-partum, in a double-blinded, randomised placebo-controlled trial. Methods: Stool samples were collected at multiple timepoints from 74 mother–infant pairs as part of a larger, double-blinded, randomised controlled allergy intervention trial. The participants were randomised to one of two groups; with one group receiving 14.2 g per day of prebiotic powder (galacto-oligosaccharides GOS and fructo-oligosaccharides FOS in ratio 9:1), and the other receiving a placebo powder consisting of 8.7 g per day of maltodextrin. The faecal microbiota of both mother and infants were assessed based on the analysis of bacterial 16S rRNA gene (V4 region) sequences, and short chain fatty acid (SCFA) concentrations in stool. Results: Significant differences in the maternal microbiota profiles between baseline and either 28-weeks’ or 36-weeks’ gestation were found in the prebiotic supplemented women. Infant microbial beta-diversity also significantly differed between prebiotic and placebo groups at 12-months of age. Supplementation was associated with increased abundance of commensal Bifidobacteria in the maternal microbiota, and a reduction in the abundance of Negativicutes in both maternal and infant microbiota. There were also changes in SCFA concentrations with maternal prebiotics supplementation, including significant differences in acetic acid concentration between intervention and control groups from 20 to 28-weeks’ gestation. Conclusion: Maternal prebiotic supplementation of 14.2 g per day GOS/FOS was found to favourably modify both the maternal and the developing infant gut microbiome. These results build on our understanding of the importance of maternal diet during pregnancy, and indicate that it is possible to intervene and modify the development of the infant microbiome by dietary modulation of the maternal gut microbiome.
Preeclampsia In Ghana: A Study On The Prevalence And Risk Factors Of Postpartum Readmission In The Ashanti Region, Enoch Odame Anto, Wina Ivy Ofori Boadu, Lovelace Kwaku Gyamfi, Emmanuel Ekow Korsah, Ezekiel Ansah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Augustine Tawiah, Elizabeth Aboagye, Albright Etwi-Mensah, Agartha Odame Anto, Christian Obirikorang
Preeclampsia In Ghana: A Study On The Prevalence And Risk Factors Of Postpartum Readmission In The Ashanti Region, Enoch Odame Anto, Wina Ivy Ofori Boadu, Lovelace Kwaku Gyamfi, Emmanuel Ekow Korsah, Ezekiel Ansah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Augustine Tawiah, Elizabeth Aboagye, Albright Etwi-Mensah, Agartha Odame Anto, Christian Obirikorang
Research outputs 2022 to 2026
Background: Despite significant improvements in its management, preeclampsia continues to be one of the frequent causes of postpartum readmission. Increased awareness of the risk factors for postpartum readmission is required to reduce its incidence and related complications. This study determined the prevalence and associated risk factors for postpartum readmission among women with preexisting preeclampsia in a Ghanaian population. Methods: This hospital-based retrospective study was conducted at the obstetrics and gynaecology units of Komfo Anokye Teaching Hospital in Ghana. We reviewed the medical records including sociodemographic and obstetric characteristics of preeclampsia patients. Statistical analyses were performed using Statistical Package for Social …
Maternal Health Considerations: Highlighting And Advancing Opportunities For Improved Maternal Health, Caitlin Fox-Harding
Maternal Health Considerations: Highlighting And Advancing Opportunities For Improved Maternal Health, Caitlin Fox-Harding
Research outputs 2022 to 2026
The special collection on Maternal Health Considerations offers a comprehensive exploration of critical issues surrounding maternal well-being across diverse contexts and disciplines. Recognising that maternal health extends beyond the physiological realm, this collection delves into the multifaceted dimensions of maternal well-being, including physical, mental, and socio-ecological factors. The collection comprises a series of interdisciplinary studies that investigate various facets of maternal health, from conception to postpartum stages. It addresses the complex interplay between biological, psychological, and socio-cultural determinants that influence maternal health outcomes. By adopting a holistic approach, the contributors shed light on the interconnectedness of maternal well-being. Key themes …
Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead
Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead
Research outputs 2022 to 2026
Background: Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. Methods: PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched. Two independent reviewers screened, extracted, and quality-appraised the studies using JBI SUMARI software. Forest plots were created with the standardized mean difference using the random-effects model, and heterogeneity was assessed using I2. …
Study Protocol For A Stepped-Wedge Cluster (Nested) Randomized Controlled Trial Of Antenatal Colostrum Expression (Ace) Instruction In First-Time Mothers: The Ace Study, Cassandra Cuffe, Roslyn Giglia, Matthew N. Cooper, Julie Hill, Desiree Silva, Anita M. Moorhead, Valerie Verhasselt, Joshua R. Lewis, Deborah Ireson, Jill R. Demirci, Talea Cotte, Kathryn Webb, Frances Patey, Therese A. O’Sullivan
Study Protocol For A Stepped-Wedge Cluster (Nested) Randomized Controlled Trial Of Antenatal Colostrum Expression (Ace) Instruction In First-Time Mothers: The Ace Study, Cassandra Cuffe, Roslyn Giglia, Matthew N. Cooper, Julie Hill, Desiree Silva, Anita M. Moorhead, Valerie Verhasselt, Joshua R. Lewis, Deborah Ireson, Jill R. Demirci, Talea Cotte, Kathryn Webb, Frances Patey, Therese A. O’Sullivan
Research outputs 2022 to 2026
Background: Although many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers. Methods and Planned Analysis: This multicenter stepped-wedge cluster (nested) randomized controlled trial aims to recruit 945 nulliparous pregnant individuals. The trial is conducted in two phases. During Phase 1, control group participants are under standard care. …
Pain Assessment Tools For Use In Infants: A Meta-Review, Diana Arabiat, Evalotte Mörelius, Kreshnik Hoti, Jeffery Hughes
Pain Assessment Tools For Use In Infants: A Meta-Review, Diana Arabiat, Evalotte Mörelius, Kreshnik Hoti, Jeffery Hughes
Research outputs 2022 to 2026
Background: Identifying pain in infants is challenging due to their inability to self-report pain, therefore the availability of valid and reliable means of assessing pain is critical. Objective: This meta-review sought to identify evidence that could guide the selection of appropriate tools in this vulnerable population. Methods: We searched Scopus, Medline, Embase, CINAHL, MIDRIS, EMCare and Google Scholar for eligible systematic reviews. Eligible reviews documented psychometric properties of available observational tools used to assess pain in infants. Results: A total of 516 reviews were identified of which 11 met our inclusion criteria. We identified 36 pain assessment tools (evaluated in …
Preliminary Efficacy, Feasibility And Safety Of Intra-Umbilical Oxytocin To Reduce The Time To Placental Delivery At Caesarean Section: An Exploratory Randomized Trial, Katrin Middleton, Fungai Mbengo, Thandisizwe R. Mavundla, George J. Hofmeyr
Preliminary Efficacy, Feasibility And Safety Of Intra-Umbilical Oxytocin To Reduce The Time To Placental Delivery At Caesarean Section: An Exploratory Randomized Trial, Katrin Middleton, Fungai Mbengo, Thandisizwe R. Mavundla, George J. Hofmeyr
Research outputs 2022 to 2026
Background: Delayed placental separation either after vaginal birth or caesarean birth is an important cause of postpartum haemorrhage, among other causes such as uterine atony. Intra-umbilical oxytocin has been shown to reduce the time to placental delivery after vaginal birth. However, the efficacy of intra-umbilical oxytocin to reduce the time to placental delivery following caesarean section birth is not known. Objectives: To explore the preliminary efficacy, feasibility and safety of intra-umbilical oxytocin to reduce the time to placental delivery at caesarean section. Methods: A double-blind, placebo-controlled, exploratory randomized clinical trial was conducted at a tertiary hospital in the Eastern Cape …