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Full-Text Articles in Nursing
Early Onset Alzheimer’S Disease In Individuals With Down Syndrome: Explored Theories Of Pathophysiology, Amanda Pack
Early Onset Alzheimer’S Disease In Individuals With Down Syndrome: Explored Theories Of Pathophysiology, Amanda Pack
Nursing Student Class Projects (Formerly MSN)
This presentation is a focus on some of the theories of the pathophysiology of early-onset Alzheimer’s Disease (AD) in individuals with Down Syndrome (DS). Down Syndrome, a genetic condition where an individual has a partial or full extra chromosome 21, is the most common chromosomal condition in the United States (National Down Syndrome Society (NDSS), 2012). Average life expectancy for individuals with DS has vastly increased in the last thirty years from age 25 to age 60 (NDSS, 2012). The extra chromosome genetically makes individuals with DS predisposed to certain conditions, including early onset dementia and AD, therefore as their …
Early-Onset Familial Alzheimer Disease, Laura J. Murphy
Early-Onset Familial Alzheimer Disease, Laura J. Murphy
Nursing Student Class Projects (Formerly MSN)
An Alzheimer’s diagnosis is an overwhelming and devastating diagnosis for both patients and families. Now imagine if this diagnosis was made at age 55. Instead of looking forward to retirement and grandchildren, these people are preparing for a debilitating disease that will rob them of their memory, cognitive and functional abilities. Early-onset familial Alzheimer’s disease (EOFAD) affects people before the age of 65. Although extremely rare, some exhibit symptoms as early as in their 30s. One of the things most frustrating about this disease is so little is known about its cause. That and the fact there is no cure. …
Apathy, Genetics, And Functional Status In Persons With Alzheimer Disease, Emilie Dykstra Goris
Apathy, Genetics, And Functional Status In Persons With Alzheimer Disease, Emilie Dykstra Goris
Faculty Publications
Background/Significance: Alzheimer Disease (AD) is an irreversible dementia that progressively destroys cognitive and daily functioning. About 5.4 million Americans currently suffer from AD, with estimated prevalence to reach 16 million by 2050 (Alzheimer's Association, 2012). AD is often regarded with fear, as most affected individuals eventually fail to recognize loved ones, lose the ability to care for themselves, and may display negative neuropsychiatric behaviors, such as apathy. Apathy is a disorder of motivation with deficits in behavioral, emotional, and/or cognitive domains and is conceptualized as a need-driven behavior, based on the Need-Driven Dementia-Compromised Behavior Model (Algase et al., 1996). Problem: …