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Saitohin And Apoe Polymorphisms Influence Cognition And Function In Persons With Advanced Alzheimer Disease, D. Schutte, D. Reed, S. Decrane, Anne Ersig
Saitohin And Apoe Polymorphisms Influence Cognition And Function In Persons With Advanced Alzheimer Disease, D. Schutte, D. Reed, S. Decrane, Anne Ersig
Anne L. Ersig
BACKGROUND/AIMS: Alzheimer disease (AD) is characterized by variability in the onset and progression of cognitive, functional and behavioral symptoms. The purpose of this study was to identify genetic correlates of symptom variability in persons with moderate-to-advanced AD. METHODS: Repeated measures of cognition, function and behavior were collected from institutionalized persons with AD over 12 months. Candidate genes were assayed. RESULTS: Single polymorphisms within the saitohin and APOE genes were associated with increased cognitive impairment and functional dependence. The APOE-epsilon4 allele was associated with increased baseline physical agitation. CONCLUSION: The development of predictive profiles for the clinical symptoms of AD may …
Communication, Encouragement, And Cancer Screening In Families With And Without Mutations For Hereditary Nonpolyposis Colorectal Cancer: A Pilot Study, Anne Ersig, Janet Williams, D. Hadley, L. Koehly
Communication, Encouragement, And Cancer Screening In Families With And Without Mutations For Hereditary Nonpolyposis Colorectal Cancer: A Pilot Study, Anne Ersig, Janet Williams, D. Hadley, L. Koehly
Anne L. Ersig
PURPOSE: Known and suspected mutation carriers for hereditary nonpolyposis colorectal cancer are advised to have colonoscopies every 1 to 2 years to detect colorectal cancer. Little is known about colonoscopy completion in families suspected of having hereditary nonpolyposis colorectal cancer but without identified mutations. METHODS: This study examined the effect of communication and encouragement on colonoscopy in families with and without known mutations. Twenty-three respondents from 11 families with indeterminate genetic test results were matched with 23 respondents from 11 families with mutation-positive results. Hierarchical modeling examined the effects of relational characteristics on time since last colonoscopy in index cases …