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Explanations Of Risk In Families Without Identified Mutations For Hereditary Nonpolyposis Colorectal Cancer, Anne Ersig, Lioness Ayres, D. Hadley, L. Koehly
Explanations Of Risk In Families Without Identified Mutations For Hereditary Nonpolyposis Colorectal Cancer, Anne Ersig, Lioness Ayres, D. Hadley, L. Koehly
Anne L. Ersig
Purpose: Genetic testing for hereditary forms of cancer does not always identify a causative mutation. Little is known about personal or family response to these indeterminate results when a hereditary form of cancer is suspected. This study explored thoughts about and responses to risk for hereditary nonpolyposis colorectal cancer (HNPCC) when a family member has received indeterminate genetic test results. Design: In this qualitative study, data were gathered from index cases who received indeterminate genetic test results through a longitudinal study offering genetic counseling and testing for HNPCC. First-degree relatives of these indeterminate index cases were also invited to participate …