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Disorders Of Fatty Acid Oxidation In The Era Of Tandem Mass Spectrometry In Newborn Screening, Sandra A. Banta-Wright, Kathleen C. Shelton, Michael J. Bennett
Disorders Of Fatty Acid Oxidation In The Era Of Tandem Mass Spectrometry In Newborn Screening, Sandra A. Banta-Wright, Kathleen C. Shelton, Michael J. Bennett
Faculty Publications - College of Nursing
With recent advances in laboratory technology with tandem mass spectrometry (MS/MS), the number of infants identified with a fatty acid oxidation disorder has increased dramatically. Disorders of fatty acid oxidation comprise one of the most rapidly growing groups within the field of errors of metabolism. This review will explore the recent developments in newborn screening related to the use of tandem mass spectrometry and disorders of fatty acid oxidation.
Tandem Mass Spectrometry In Newborn Screening, Sandra Banta-Wright, Robert Steiner
Tandem Mass Spectrometry In Newborn Screening, Sandra Banta-Wright, Robert Steiner
Faculty Publications - College of Nursing
Since 1961 newborn screening for errors of metabolism (EM) has improved the diagnosis, treatment and outcome of newborns with an EM. Recently, advances in laboratory technology with tandem mass spectrometry (MS/MS) has increased the identification of newborns with an EM. With a single dried filter paper blood spot (Guthrie R, Susi A. A simple phenylalanine method for detecting PKU in large populations of newborn infants. Pediatrics. 1963;32:338-343). MS/MS can identify more than 30 disorders of metabolism This review will explore MS/MS to provide a better understanding of the development and application of this technology to newborn screening for perinatal and …