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Role Of The Serotonin Transporter Gene In Resilience To Stress And Trauma: An Integrative Review, Kosuke Niitsu

Posters and Presentations: College of Nursing

Resilience is defined as a multi-dimensional dynamic concept of positive adaptation to stress and trauma. It is estimated that 38 - 52% of phenotypic variation in resilience among Americans is due to genetic variance. Among nine candidate genes associated with resilience, the promoter region of serotonin transporter gene (5- HTTLPR) is of increasing clinical interest. Accumulating evidence suggests those who carry the Short (S) allele of 5-HTTLPR may be at increased risk of developing psychopathology such as Post-Traumatic Stress Disorder (PTSD). However, little is known about whether S allele carriers are less resilient to stress and trauma compared to Long …