Mental and Social Health Commons^™

An Introduction: Quantification Of The Hippocampal Bdnf Content Of Maternally Separated Rats Using A Western Blot Protocol, Bernajane M. Palisoc, Laurel M. Pritchard, Emily Hensleigh

McNair Poster Presentations

Among industrialized nations, the United States has the worst incidence of child maltreatment with 3 million cases per year (U.S. Department of Health and Human Services, 2012). Studies have shown that individuals who were maltreated when they were young are more susceptible to drug abuse such as alcohol, cocaine, and nicotine (Maddahian, Newcomb, & Bentle, 1988). Early life stress (ELS) causes hyperactivation of the Hypothalamic-Pituitary- Adrenal (HPA) Axis (Heim et al., 2000; Plotsky et al., 2005). The dysregulation of the HPA axis causes the secretion of glucocorticoid stress hormones by large amounts, which in return attenuates hippocampal Brain-derived neurotrophic factor …

Effects Of Restraint Stress And Allopregnanolone Inhibition On Amphetamine Locomotor Sensitivity, Kelly Abuali, Laurel M. Pritchard

McNair Poster Presentations

The chronic, recurring nature of addiction remains a worldwide problem. Even after apparently successful clinical treatment and long term abstinence, individuals may still relapse many months or years later. Although many individual differences exist among substance abusers, relapse tends to occur during periods of high stress (Sinha et al., 2006). Behavioral training and therapy can help cope during these high stress times, but pharmacological interventions have not been shown to be effective (Ross & Peselow, 2009). Although some therapeutic options decrease relapse rates, more effective treatments for relapse need further consideration.

The effect of stress on use of and relapse …

Predictors Of Smoking Behavior And Readiness To Quit In Addiction Treatment, Arturo Soto-Nevarez, Joseph Guydish

McNair Poster Presentations

Background: Prevalence of tobacco use is 3 times higher for those seeking substance abuse treatment than those in the general population. Clinical practice guidelines recommend addressing smoking cessation. This population has more difficulty quitting than the general population. Methods: This paper analyzes predictors of smoking behavior and readiness to quit in patients enrolled in addiction treatment programs. Data from six substance abuse treatment centers was collected. A total of 235 clients were surveyed on their smoking attitudes and behaviors. Results: Survey data from 139 current smokers was analyzed. In logistic regression analyses predicting readiness to quit smoking, and controlling for …