Medical Sciences Commons^™

It's Just Diastolic Heart Failure, Right? A Lesson In Humility From A Patient With Ttr-Amyloid Cardiomyopathy., Nathan Brewster Do, Michael Sumner Do, Ross Biggs Do, Ronald S. Freudenberger Md

Department of Medicine

No abstract provided.

Sick Sinus Syndrome And Chronic Chagas Cardiomyopathy., Sagar Vadhar Do, Benjamin Sanchez Md

Department of Medicine

No abstract provided.

Impact Of Aspirin And Clopidogrel Hyporesponsiveness In Patients Treated With Drug-Eluting Stents: 2-Year Results Of A Prospective, Multicenter Registry Study., Thomas D. Stuckey Md, Ajay J. Kirtane Md, Bruce R. Brodie Md, Bernhard Witzenbichler Md, Claire Litherland Ms, Giora Weisz Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Paul A. Gurbel Md, Roxana Mehran Md, Philippe Généreux Md, Ori Ben-Yehuda Md, Charles A. Simonton Md, Gregg W. Stone Md

Department of Medicine

OBJECTIVES: In this analysis of 2-year outcomes in the ADAPT-DES (Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents) study, the authors sought to examine the independent associations between platelet reactivity to both aspirin and clopidogrel and subsequent outcomes.

BACKGROUND: The relationship between platelet reactivity and long-term adverse events following implantation of drug-eluting stents (DES) has been incompletely characterized.

METHODS: The ADAPT-DES study was a multicenter registry of patients undergoing routine platelet function testing following percutaneous coronary intervention with DES. The primary study endpoint was definite or probable stent thrombosis (ST); other endpoints were all-cause mortality, myocardial infarction, and clinically relevant …

Trends Of Revascularization In Acute Myocardial Infarction Patients With Coronary Artery Anomalies: A Nationwide Analysis Of 8,131 Patients., Neeraj Shah Md, Vratika Agarwal Md, Nainesh C. Patel Md

Department of Medicine

No abstract provided.

Rhabdomylosis Induced Type 1 Pattern Brugada Syndrome: A Differential Not To Be Forgotten, Ross Biggs Do, Jahangir Khan Md, Q Muhammed Md, Babak Bozorgnia Md

Department of Medicine

No abstract provided.

A Ruptured Basilar Aneurysm Resulting In Takotsubo Cardiomyopathy., Ryan Murphy Do, Apurva Vyas Md, Megan Leary Md

Department of Medicine

No abstract provided.

Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Venticular Dysplasia., Ross Biggs Do, Brijesh Patel Md, Matthew W. Martinez Md, Matthew Mccambridge Md, Susan Kim Md, Norman Marcus Md

Department of Medicine

No abstract provided.

Eosinophilic Heart Disease: A Case Report And Review Of Literature (Poster)., Ghulam Akbar Md, Fnu Vikram, Ronald S. Freudenberger Md, Matthew W. Martinez Md

Department of Medicine

No abstract provided.

Rare Case Of Congenital Absence Of Left Atrial Appendage And Afib., Fnu Vikram, Ghulam Akbar Md, Ghazi Mirrani Md, Aurangzeb Baber Md, Amy M. Ahnert Md

Department of Medicine

No abstract provided.

Impact Of Atrial Fibrillation On Outcomes In Patients Hospitalized With St-Segment Elevation Myocardial Infarction (Poster)., Lohit Garg Md, Sahil Agrawal Md, Manyoo Agarwal Md, Aakash Garg Md, Amitoj Singh, Nirmanmoh Bhatia, Mahek Shah Md, Brijesh Patel Md, Sudip Nanda Md, Facp, David A. Cox Md

Department of Medicine

No abstract provided.

An Over-The-Counter Treatment For Diarrhea Leading To Euphoria And Fatal Arrhythmia., Angela Magdaleno, Michael Sumner Do, Travis Magdaleno Md, Justin L. Guthier Do, Apurva Vyas Md

Department of Medicine

No abstract provided.

Impact Of Atrial Fibrillation On Outcomes In Patients Hospitalized With St- Segment Elevation Myocardial Infarction., Lohit Garg Md, Sahil Agrawal Md, Manyoo Agarwal Md, Aakash Garg Md, Amitoj Singh, Nirmanmoh Bhatia, Mahek Shah Md, Brijesh Patel Md, Sudip Nanda Md, Facp, David A. Cox Md

Department of Medicine

Background: Atrial fibrillation (AF) is reported in 7-19% patients with acute ST- Segment Elevation Myocardial Infarction (STEMI). There is

a paucity of data on the impact of AF on outcomes in patients with acute STEMI.

Methods: We queried the National Inpatient Sample (NIS) database for years 2003- 2013 to identify all patients >=18 years of age

admitted with acute STEMI.

Results: Of the total 2,632,447 STEMI hospitalizations, AF was documented in 339,987 (12.9%) patients. At baseline, patients with

AF were older (mean 74 vs 63 years, p

Hypertension, renal failure, diabetes mellitus and congestive heart failure were all more prevalent …

Sports Cardiology: Core Curriculum For Providing Cardiovascular Care To Competitive Athletes And Highly Active People., Aaron L. Baggish Md, Robert W. Battle Md, James G. Beckerman Md, Alfred A. Bove Md, Phd, Rachel J. Lampert Md, Benjamin D. Levine Md, Mark S. Link Md, Matthew W. Martinez Md, Silvana M. Molossi Md, Phd, Jack Salerno Md, Meagan M. Wasfy Md, Rory B. Weiner Md, Michael S. Emery Md

Department of Medicine

The last few decades have seen substantial growth in the populations of competitive athletes and highly active people (CAHAP). Although vigorous physical exercise is an effective way to reduce the risk of cardiovascular (CV) disease, CAHAP remain susceptible to inherited and acquired CV disease, and may be most at risk for adverse CV outcomes during intense physical activity. Traditionally, multidisciplinary teams comprising athletic trainers, physical therapists, primary care sports medicine physicians, and orthopedic surgeons have provided clinical care for CAHAP. However, there is increasing recognition that a care team including qualified CV specialists optimizes care delivery for CAHAP. In recognition …

Tct-732 Relationship Between Stent Diameter, Platelet Reactivity, And Adverse Events After Pci: Analysis From The Adapt-Des Study., Björn Redfors, Philippe Généreux Md, Bernhard Witzenbichler Md, Ajay J. Kirtane Md, Thomas Mcandrew, Bruce R. Brodie Md, Michael J. Rinaldi Md, Timothy D. Henry Md, David A. Cox Md, Ernest L. Mazzaferri Md, Ori B. Yehuda, Roxana Mehran Md, Gregg W. Stone Md

Department of Medicine

Background

Small vessel diameter and residual high platelet reactivity (HPR) have both been associated with adverse events after PCI. We sought to determine whether a specific interaction exists between HPR and stent diameter in regard to outcomes after PCI.

Methods

We stratified pts in the prospective ADAPT-DES registry who underwent successful single-lesion PCI with DES according to whether or not they received only small diameter stents (diameter ≤2.5 mm). Pts receiving ≤2.5 mm stents were compared to pts receiving a stent with a diameter >2.5 mm using propensity score (PS) adjusted Cox proportional hazards regression. HPR was defined as P2Y12 …

A Case Of Recurrent Cerebrovascular Accident In The Setting Of Cardiac Papillary Fibroelastoma., Jahangir Khan Md, Matthew Sullivan Do, Amy M. Ahnert Md

Department of Medicine

No abstract provided.

Tct-733 Association Between Hypertension, Platelet Reactivity, And The Risk Of Adverse Events After Pci: Analysis From The Adapt-Des Study, Björn Redfors, Xin Huang, Bernhard Witzenbichler Md, Shmuel Chen, Yangbo Liu, Bruce R. Brodie Md, Michael J. Rinaldi Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Roxana Mehran Md, Ajay J. Kirtane Md, Ori B. Yehuda, Gregg W. Stone Md

Department of Medicine

No abstract provided.

Tct-546 Performance Of The Dual Antiplatelet Therapy (Dapt) Score In The Adapt-Des Study., Sorin J. Brener, Ajay J. Kirtane Md, Michael J. Rinaldi Md, Bernhard Witzenbichler Md, Franz-Josef Neumann Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest Mazzaferri Md, Bruce R. Brodie Md, Roxana Mehran Md, Thomas Mcandrew, Gregg W. Stone Md

Department of Medicine

Background

The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remains in dispute, particularly after 12 months. The DAPT Score was developed from the DAPT trial to identify pts who may benefit the most from extended therapy. We sought to assess the performance of the DAPT risk score in the all-comers Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents (ADAPT-DES) registry, and to test the utility of additional predictors of events on its performance.

Methods

Patients free from ischemic or hemorrhagic events after 1 year of DAPT after successful DES implantation were analyzed. The DAPT score …

Tct-353 Underweight Status, Platelet Reactivity, And 2-Year Clinical Outcomes In Patients Undergoing Pci With Des: An Adapt-Des Study Analysis., Puja B. Parikh Md, Ajay J. Kirtane Md, Giora Weisz Md, Thomas D. Stuckey Md, M Ozgu Ozan Ms, Bernhard Witzenbichler Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Bruce R. Brodie Md, Ernest Mazzaferri Md, Roxana Mehran Md, Gregg W. Stone Md

Department of Medicine

Background

The relationships between underweight status, platelet reactivity, and clinical outcomes after PCI with DES are not well understood.

Methods

ADAPT-DES was a prospective, multicenter study of 8582 pts treated with aspirin and clopidogrel in whom routine measurement of P2Y12 reaction units (PRU) by VerifyNow testing was performed following successful DES implantation. Pts were classified according to the following body mass index (BMI) groups: Underweight (BMI/m2), normal weight (20 kg/m2 ≤ BMI/m2), overweight (25 kg/m2 ≤ BMI/m2), and obese (BMI ≥30 kg/m2).

Results

Underweight pts were more often female, smokers, had higher rates of peripheral arterial disease and renal insufficiency, …

Tct-352 Proportion Of Ischemic Risk After Pci Mediated By High Platelet Reactivity On Clopidogrel: Analysis From The Adapt-Des Study., Björn Redfors, Ori Ben-Yehuda Md, Sheng-Hsuan Lin, Ariel Furer, Ajay J. Kirtane Md, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Akiko Maehara Md, Philippe Généreux Md, Gennaro Giustino Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Girma M. Ayele, Roxana Mehran Md, Gary Mintz, Gregg W. Stone Md

Department of Medicine

No abstract provided.

Tct-237 Outcomes After Successful Pci Of Severely Calcified Lesions Using Rotational Atherectomy, Cutting Balloon, Or Balloon Angioplasty Only Before Second-Generation Drug-Eluting Stent Implantation., Björn Redfors, Philippe Généreux Md, Akiko Maehara Md, Ajay J. Kirtane Md, Rushad Dordi, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Claire Litherland Ms, Roxana Mehran Md, Gary Mintz, Gregg W. Stone Md

Department of Medicine

No abstract provided.

Cardiac Consequences Of The Heroin Epidemic: Loperamide Causing Torsades De Pointes, Justin L. Guthier Do, Apurva Vyas Md

Department of Medicine

No abstract provided.

Primary Malignant Pleural Effusion With A Profound Type B Lactic Acidosis, Rachel Kinney Do, Christine Saraceni Do, Eliot L. Friedman Md

Department of Medicine

No abstract provided.

Therapeutic Hypothermia And Stent Thrombosis: A Nationwide Analysis., Neeraj Shah Md, Rahul Chaudhary Md, Kathan Mehta, Vratika Agarwal Md, Jalaj Garg Md, Ronald S. Freudenberger Md, Larry E. Jacobs Md, David A. Cox Md, Karl B. Kern Md, Nainesh C. Patel Md

Department of Medicine

OBJECTIVES: This study sought to determine whether "real-world" data supported the hypothesis that therapeutic hypothermia (TH) led to increased rates of stent thrombosis.

BACKGROUND: TH, which is often instituted after cardiac arrest (CA) to improve neurologic outcomes, alters pharmacokinetics of antiplatelet medications, leading to a theoretical risk of stent thrombosis after percutaneous coronary intervention (PCI).

METHODS: CA patients with acute myocardial infarction undergoing PCI were identified from the Nationwide Inpatient Sample from 2006 to 2011, with a defined primary outcome of stent thrombosis. The incidence of stent thrombosis in patients undergoing TH versus those not undergoing TH was compared using …

Incidence Of Deep Vein Thrombosis In Patients Undergoing Right Internal Jugular Vein Cannulation For Veno-Venous Extracorporeal Membrane Oxygenation, Taryn Samet Md, Timothy S. Misselbeck, Rita Pechulis Md, Fccp, James A. Burke Md, Phd, James K. Wu Md, Nicole Stansbury

Department of Medicine

No abstract provided.

The Impact Of Timing Of Ischemic And Hemorrhagic Events On Mortality After Percutaneous Coronary Intervention: The Adapt-Des Study., Sorin J. Brener, Ajay J. Kirtane Md, Thomas D. Stuckey, Bernhard Witzenbichler Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Roxana Mehran Md, Rupa Parvataneni Ms, Bruce R. Brodie Md, Gregg W. Stone Md

Department of Medicine

OBJECTIVES: The aim of this study was to understand the impact of the timing of ischemic and hemorrhagic events after percutaneous coronary intervention (PCI) with drug-eluting stents on subsequent mortality.

BACKGROUND: These events have been strongly associated with subsequent death.

METHODS: In the multicenter, prospective ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug Eluting Stents) study, patients at 11 clinical sites with successful PCI with drug-eluting stents underwent assessment of platelet function and were followed for 2 years. Events occurring after PCI-definite or probable stent thrombosis (ST), myocardial infarction (MI) not related to ST, and clinically relevant bleeding (CB)-were classified …

Role Of Prophylactic Magnesium Supplementation In Prevention Of Postoperative Atrial Fibrillation In Patients Undergoing Coronary Artery Bypass Grafting: A Meta-Analysis Of 23 Randomized Controlled Trials (Poster)., Jalaj Garg Md, Rahul Chaudhary Md, Parasuram Krishnamoorthy Md, Neeraj Shah Md, Babak Bozorgnia Md

Department of Medicine

No abstract provided.

Transcatheter Aortic Valve Replacement Is Associated With A Higher Rate Of Permanent Pacemaker Implantation Compared To Surgical Aortic Valve Replacement: A Propensity Matched Analysis (Poster)., Neeraj Shah Md, Achint Patel Mbbs, Nileshkumar Patel Md, Vratika Agarwal Md, Jalaj Garg Md, Nainesh C. Patel Md, Facc, David A. Cox Md, Facc, Fscai

Department of Medicine

Predictors Of Coronary Artery Disease In Patients With Polycythemia Vera And Essential Thrombocytosis: Results From The National Inpatient Sample 2009-10., Parasuram Krishnamoorthy Md, Varun Mittal, Jalaj Garg Md, Neeraj Shah Md, Nainesh C. Patel Md

Department of Medicine

Background: Myelproliferative disorders (MPDs) including Polycythemia Vera (PCV) and Essential thrombocytosis (ET) are associated with increase in arterial and venous thromboembolic events. Chronic endothelial damage, hyperviscosity and platelet activation are possible mechanistic factors resulting in accelerated atherogenesis and coronary artery disease (CAD). However the differences in prevalence of CAD and traditional risk factors (TRFs) between PCV and ET are unknown. Hence, we aimed to determine the prevalence and predictors of CAD in PCV and ET patients using a national registry.

Methods: All patients ≥18 years diagnosed with PCV and ET were identified in the Nationwide Inpatient Sample (NIS) 2009-2010 …

Dust Off Huffing: Emerging As A New And Cheap Form Of Abuse And A Cause Of Different Types Of Arrhythmias With Transient Multiorgan Failure, Deepika Jain Md, Raman Dusaj Md

Department of Medicine

No abstract provided.

Prognostic Significance Of Tissue Oxygen Saturation Using Near Infrared Spectroscopy In Patients Undergoing Therapeutic Hypothermia After Cardiac Arrest, Adrian C. Bell Do, Ataul Qureshi Md, Stephen Awuor Md, Sanjeev U. Nair Md, Agei Enoh Md, Daniel J. Makowski Do, Charity Curtis Mph, Nainesh Patel Md, Facc, Bruce Feldman Do, Facc

Department of Medicine

No abstract provided.