Health and Medical Administration Commons^™

Serum Gamma-Glutamyltransferase And The Risk Of Type 2 Diabetes In A Population-Based Cohort Study Of Older Mexican Americans, Lynn Blythe

Master's Theses and Doctoral Dissertations

Our objective was to test the hypothesis that increased GGT predicts an increased risk of type 2 diabetes (T2D) in elderly Mexican Americans.

Data from a population-based cohort study of 1789 community-dwelling Mexican American men and women, aged 60-101, in the SALSA study were used. Data for 1,203 participants without diabetes at baseline were evaluated for incident diabetes. Proportional hazard models were used to predict the probability of incident T2D by GGT level.

After adjustment for age, gender, smoking, alcohol use, and BMI, the risk of developing T2D associated with GGT was significant at 1.4 (95% CI 1.2 -1.7). However, …

Approval Of New Drugs By The U. S. Food And Drug Administration: Problems With The Process And Access To Unapproved Drugs, Christine M. Hoeft-Loyer

Master's Theses and Doctoral Dissertations

Today, the vast majority of drugs available for patient use have gone through a rigorous system of human clinical trials supervised by the Food and Drug Administration (FDA), to ensure the drugs are safe and efficacious. There are now citizen advocacy groups that seek use of drugs not yet approved by the FDA, to be administered to terminally ill patients who have exhausted all other available means of therapy. The FDA has programs for terminal patients, under the supervision of their physicians, to use unapproved drugs; however, the advocacy groups seek access to drugs in much earlier phases than is …

Identification Of Symptom Domains In Ulcerative Colitis That Occur Frequently During Flares And Are Responsive To Changes In Disease Activity, Tahira M. Khan

Master's Theses and Doctoral Dissertations

The aim of this study was to determine which symptom domains in ulcerative colitis (UC) are important in the evaluation of disease activity. An important symptom is that which 1) occurs during flares, 2) improves during effective therapy, and 3) resolves during remission. Twenty eight symptom domains were evaluated. Sixty subjects were surveyed, rating each symptom on three criteria with a 100 mm Visual Analog Scale (VAS). Important symptoms were defined a priori as those whose median VAS rating for all 3 criteria was significantly greater than 50. Thirteen of the 28 symptom domains proved to be both frequent in …