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Articles 1 - 3 of 3
Full-Text Articles in Dentistry
The Effect Of Single Nucleotide Polymorphisms (Snps) In Toll-Like Receptors -2, -4, -9, And Cd14 Genes In An African-American Population With Chronic Periodontitis, Willard Maughan
Theses and Dissertations
AIM: to determine if a relationship exists between TLR-2, TLR-4, TLR-9, or CD14 polymorphisms and risk for developing chronic periodontal disease in an African-American population. This is the first study conducted to determine role of SNPs in TLR genes and CD14 gene in a periodontally-diseased African-American population. Additionally, this is the first study to assess the role of TLR-9 polymorphism in periodontitis patients. METHODS: A total of 130 subjects were involved in the study. The chronic periodontitis (CP) group contained 73 subjects, and the healthy control (NP) group 57subjects. Genotyping was performed in TLR2 (G2408A), TLR4 (A896G),TLR9 (T1486C) and CD14 …
Differential Stimulation Of Monocytes To Secrete Secretory Leukocyte Protease Inhibitor By Lipopolysaccharide Of Periodontal Pathogens, Jason Todd Primm
Differential Stimulation Of Monocytes To Secrete Secretory Leukocyte Protease Inhibitor By Lipopolysaccharide Of Periodontal Pathogens, Jason Todd Primm
Theses and Dissertations (ETD)
Lipopolysaccharide (LPS), or endotoxin, is the major component of the outer surface of gram-negative bacteria. LPS is a potent activator of cells of the immune and inflammatory systems, including macrophages, monocytes, and endothelial cells, and contributes to systemic changes known as septic shock. Each LPS molecule has three regions: oligosaccharide, core, and lipid A. Oligosaccharide is exposed on the cell surface, and lipid A anchors LPS in the outer membrane. Recent studies from our lab demonstrated that LPS of periodontal pathogens suppresses neutrophil's ability to secrete super oxide ions and also shown it to interfere with neutrophil chemotaxis. These factors …
Periodontitis, Inflammatory Markers And Solid Organ Transplant Recipients, Murad Hadi Shaqman
Periodontitis, Inflammatory Markers And Solid Organ Transplant Recipients, Murad Hadi Shaqman
SoDM Masters Theses
No abstract provided.