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Full-Text Articles in Dentistry
6th Annual Pacific Research Day Abstracts, University Of The Pacific
6th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
On The Formulation Of Ph-Sensitive Liposomes With Long Circulation Times, Sérgio Simões, João Nuno Moreira, Cristina Fonseca, Nejat Düzgüneş, Maria C. Pedroso De Lima
On The Formulation Of Ph-Sensitive Liposomes With Long Circulation Times, Sérgio Simões, João Nuno Moreira, Cristina Fonseca, Nejat Düzgüneş, Maria C. Pedroso De Lima
All Dugoni School of Dentistry Faculty Articles
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, and facilitation of intracytoplasmic delivery. pH-sensitive liposomes have been developed to mediate the introduction of highly hydrophilic molecules or macromolecules into the cytoplasm. These liposomes destabilize under acidic conditions found in the endocytotic pathway, and usually contain phosphatidylethanolamine (PE) and titratable stabilizing amphiphiles. Formulations without PE have also been developed. Encapsulated compounds are thought to be transported into the cytoplasm through destabilization of or fusion with the endosome membrane. Incorporation of a low mole …