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Full-Text Articles in Dentistry
Inhibition Of Candida Albicans And Mixed Salivary Bacterial Biofilms On Antimicrobial Loaded Phosphated Poly(Methyl Methacrylate), Andrew R. Dentino, Dong Hwa Lee, Kelley Dentino, Arndt Guentsch, Mohammadreza Tahriri
Inhibition Of Candida Albicans And Mixed Salivary Bacterial Biofilms On Antimicrobial Loaded Phosphated Poly(Methyl Methacrylate), Andrew R. Dentino, Dong Hwa Lee, Kelley Dentino, Arndt Guentsch, Mohammadreza Tahriri
School of Dentistry Faculty Research and Publications
Biofilms play a crucial role in the development of Candida-associated denture stomatitis. Inhibition of microbial adhesion to poly(methyl methacrylate) (PMMA) and phosphate containing PMMA has been examined in this work. C. albicans and mixed salivary microbial biofilms were compared on naked and salivary pre-conditioned PMMA surfaces in the presence or absence of antimicrobials (Cetylpyridinium chloride [CPC], KSL-W, Histatin 5 [His 5]). Polymers with varying amounts of phosphate (0–25%) were tested using four C. albicans oral isolates as well as mixed salivary bacteria and 24 h biofilms were assessed for metabolic activity and confirmed using Live/Dead staining and confocal microscopy. …