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Full-Text Articles in Dentistry
The Relative Occlusal Force Of Natural Tooth Adjacent To Distal Extension Implant Support Fixed Prosthesis Using T-Scan Analysis : A Cross Sectional Study, Chin Purintarapiban
The Relative Occlusal Force Of Natural Tooth Adjacent To Distal Extension Implant Support Fixed Prosthesis Using T-Scan Analysis : A Cross Sectional Study, Chin Purintarapiban
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This cross-sectional study aimed to compare the relative occlusal force between implant in the distal end and tooth adjacent to implant in maximum intercuspation. Methodology: Patients with implant restoration replacing teeth in free end space adjacent to natural tooth were recalled. The occlusion is examined as shim stock passes through the occluded tooth in heavy or light bites. The heavy bite or a light bite with shim stock that cannot pull through is HB1 or LB1. If the shim stock can pull through it is considered HB0 or LB0. The implant is classified into 3 groups, HB1LB0, HB1LB1, and …
Efficacy Of Chitosan Paste As Intracanal Medication Against Enterococcus Faecalis And Candida Albicans Compared To Calcium Hydroxide, Pasika Thien-Ngern
Efficacy Of Chitosan Paste As Intracanal Medication Against Enterococcus Faecalis And Candida Albicans Compared To Calcium Hydroxide, Pasika Thien-Ngern
Chulalongkorn University Theses and Dissertations (Chula ETD)
Introduction: Enterococcus faecalis and Candida albicans are frequently found in persistent endodontic infection and are resistant to calcium hydroxide (Ca(OH)2), a commonly used intracanal medication. Thus, an effective and safe antimicrobial medication against such refractory infection is necessary in endodontic retreatment, so we aimed to test the efficacy of chitosan paste against these microorganisms compared with Ca(OH)2 in root canals of extracted human teeth. Methods: Thirty-six sterilized human root samples prepared from extracted premolars and upper maxillary incisors were infected with E.faecalis for 14 days, while 32 were infected with C.albicans for 48 hours, for mature biofilm formation. The samples …
Accuracy Comparison Of Dental Implants Obtained By Dynamic Cais In All-On-4 Edentulous Area Among Different Types Of Bone Density: An In Vitro Study, Jutasinee Pornpolsarun
Accuracy Comparison Of Dental Implants Obtained By Dynamic Cais In All-On-4 Edentulous Area Among Different Types Of Bone Density: An In Vitro Study, Jutasinee Pornpolsarun
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Determination of available bone is particularly important in implant placement quality of bone can affect the accuracy implant placement. Currently, Dynamic navigation system illustrated the improvement of implant accuracy, The accuracy of implant placement using computer-assisted implant placement system (CAIS) is unknown. As a result, the goal of this study was to see how bone density affected implant placement accuracy with Dynamic CAIS. Purpose: To determine the effect of different bone density in the accuracy of implant placement using dynamic navigation system Materials and Methods: The study's overall design includes a single doctor planning each implant using a CBCT …
The Effectiveness Of Asiaticoside On Osteogenic Differentiation Ability In Aging Human Periodontal Ligament Cells In Vitro, Adisa Suthirathikul
The Effectiveness Of Asiaticoside On Osteogenic Differentiation Ability In Aging Human Periodontal Ligament Cells In Vitro, Adisa Suthirathikul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Retaining teeth is essential for the quality of life of the aging population. However, aging has biological effects in periodontal ligament cells with significant changes in their proliferative rate and regenerative function. Asiaticoside, extracted from Centella asiatica, was found to have potential in osteogenic differentiation and mineralization in human periodontal ligament cells (HPDLCs). The aim of this study is to investigate the effect of asiaticoside on the aging HPDLCs osteogenic differentiation and mineralization. Aging HPDLCs, retrieved from patients age 60 and above, were confirmed aging status using Senescence-Associated ß -Galactosidase assay. The cells were incubated with various concentrations of asiaticoside …
Effect Of Different Placement Methods On Voids Formationin Class Ii Cavity Restored With Bulk-Fill Resin Composite, Parinthorn Siyoputhawong
Effect Of Different Placement Methods On Voids Formationin Class Ii Cavity Restored With Bulk-Fill Resin Composite, Parinthorn Siyoputhawong
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this study was to evaluate void formation by micro-computed tomography in two-surface Class II cavities restored with two bulk-fill resin composites using different placement methods. Standardized Class II cavities were prepared in forty intact human maxillary first premolar teeth. The teeth were randomly divided into four groups and restored with (n=10): 1) one bulk placement with hand instrument; 2) two-bulk placement with hand instrument; 3) one bulk placement with injectable dispenser; 4) one bulk placement with injectable dispenser and sonic-activated handpiece. Percentage of void formation in the entire restoration was evaluated. Welch's ANOVA and Games-Howell post hoc …
A Retrospective Study In Comparison Of Skeletal Stability And Pharyngeal Airway Changes In Mandibular Prognathism After Correction With Mandibular Setback Surgery Using Two Different Types Of Osteofixation Materials, Phu Hnin Thet
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: This study compared the skeletal stability and pharyngeal airway changes after mandibular setback procedure using the titanium and resorbable plate and screws fixation. Materials and Methods: 28 patients with mandibular prognathism being treated with bilateral sagittal split ramus osteotomy (BSSRO) were randomly selected from titanium and resorbable fixations. Analyses of lateral cephalometric x-rays were performed according to preoperative (T0), 1st week post-surgery (T1), 3-6 months post-surgery (T2) and 1-year post-surgery (T3). The horizontal measurement (BX), vertical measurement (BY), and angle measurement (SNB and Mandibular Plane Angle; MPA) were studied for skeletal stability. The pharyngeal airway changes were observed by …
Factors Influencing The Dentist’S Decision To Propose A Tooth Autotransplantation In The Faculty Of Dentistry, Chulalongkorn University, Thunchanok Sinprasurdsook
Factors Influencing The Dentist’S Decision To Propose A Tooth Autotransplantation In The Faculty Of Dentistry, Chulalongkorn University, Thunchanok Sinprasurdsook
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: To study factors which influence a dentist’s decision to propose the Tooth Autotransplantation (AT). Material and methods: A cross-sectional study was conducted among 99 dentists between January and March 2021. A questionnaire comprised demographic characteristics, unprimed scenario, primed scenario, reasoning behind decisions, experience, and knowledge of AT. Data were analyzed using the Chi-square test, McNemar’s test, and multiple logistic regression. Results: The respondents comprised 73 females and 26 males with a mean age of 30.84 ± 6.238 years. In the unprimed scenario, there were significant associations between fields of expertise, experience, knowledge of current indications, outcomes, and the benefits …
Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi
Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi
Chulalongkorn University Theses and Dissertations (Chula ETD)
In the clinical situation, pulp exposure can happen during caries removal procedures. Inflammation can occur on the pulp of the exposed area because of infiltration of bacteria from caries or as a result of pulp reaction to caries removal drilling. When the pulp was exposed during the caries removal procedure, traditional methods to preserve the pulp such as pulp capping and pulpotomy were performed. The ideal treatment outcome of the pulp exposure is to regain the primary structure of tubular dentin as well as maintain the vitality and healthiness of the dental pulp Thus, good dental materials or drugs used …
Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul
Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul
Chulalongkorn University Theses and Dissertations (Chula ETD)
[Background] This study aimed to explore differences in vowel production using acoustic analysis in skeletal Class III and Class I Japanese participants, and to investigate the correlation between vowel sounds and cephalometric variables in skeletal Class III subjects. [Materials and Methods] Japanese males with skeletal Class III (ANB<0°) and Class I skeletal relationships (0.62°
Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos
Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: The purpose of this study was to investigate the effect of Ca2+ on proliferation, osteogenic differentiation, and migration of stem cells from human exfoliated teeth (SHEDs) in vitro Materials and methods: SHEDs were seeded in culture media and osteogenic induction media containing 1.8-16.2 mM of Ca2+. SHEDs proliferation was determined using MTT assay and colony forming unit assay. Osteogenic differentiation was evaluated using mineralization assay and osteogenic marker gene expression and cell migration was evaluated using wound healing assay. Values were expressed as mean + S.D. Statistical analysis of MTT assay and wound healing assay were performed using two-way …
Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn
Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The complete regeneration of periodontal tissues following current periodontal therapy remain challenging and unpredictable. Nucleoside-modified messenger RNA (mRNA) technology can be a promising novel platform in regenerative medicine. The aims of this study were to evaluate whether pseudouridine modified mRNA encoding vascular endothelial growth factor (VEGF) could induce VEGF production in human periodontal ligament cells (PDLCs) and this translated protein function by promoting in vivo blood vessel formation using chorioallantoic membrane (CAM) assay. Isolated PDLCs from healthy periodontal tissue were transfected with modified mRNA encoding VEGF (VEGF mRNA) complexed with a transfecting agent, Lipofectamine 2000 (L2000) and L2000 alone (control). …
The Effects Of The Oral Exercises On The Oral Function Of People With Dementia, Kwanrutai Somsak
The Effects Of The Oral Exercises On The Oral Function Of People With Dementia, Kwanrutai Somsak
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this study was to examine the effects of the home-based oral exercises on the oral function in people with mild to moderate dementia. The patients with mild to moderate dementia at King Chulalongkorn Memorial Hospital, who were randomly allocated to an experimental group (n = 11), were asked to perform 3 home-based oral exercises for 3 months while those in a control group (n = 11) did not do any oral exercises. The oral function including maximum tongue pressure (MTP), oral diadochokinesis (ODK) rates of /ta/, /ka/, /pa/, swallowing function (modified water swallowing test: MWST), and oral …
Role Of Extracellular Adenosine Triphosphate (Eatp) On Immunomodulatory Function Of Human Periodontal Ligament Cells, Maythwe Kyawsoewin
Role Of Extracellular Adenosine Triphosphate (Eatp) On Immunomodulatory Function Of Human Periodontal Ligament Cells, Maythwe Kyawsoewin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Adenosine triphosphate, a nucleotide that acts as an important extracellular messenger, is released into the extracellular environment during various physiologic and pathological conditions. Human periodontal ligament cells (hPDLCs) can release adenosine triphosphate into the extracellular environment in response to mechanical stress. Extracellular adenosine triphosphate (eATP) plays role in both inflammation and osteogenic differentiation processes. eATP also participates in immunosuppressive action on immune cells. However, the role of eATP on the immunomodulatory function of hPDLCs is still unclear. This study aims to investigate the effects of eATP on the immunomodulatory function of hPDLCs and the participation of specific purinergic P2 …
Impact Of Early Childhood Caries On Oral Health-Related Quality Of Life Among 5-Year-Old Children In Mandalay, Myanmar, Saw Nay Min
Chulalongkorn University Theses and Dissertations (Chula ETD)
Purpose: The study aimed to develop the cross-cultural adaptation and psychometric properties of the Myanmar Version of SOHO-5 and assess the impact of ECC on oral health quality of life among 5-year-old children in Mandalay using the Myanmar version of the SOHO-5 questionnaire. Materials and methods: The Myanmar SOHO-5 version was conducted with the forward-backward translation method and investigated the content validity, internal consistency, test-retest reliability, construct validity, and discriminant validity on 5-year-old children and their parents in phase I. A cross-sectional study was conducted using a self-administered questionnaire to investigate the impact of ECC and relative factors on the …
A Comparison Of Implant Stability Between Two Dental Implant Designusing Two Different Stability Measuring Technique, Chanikarn Chaksupa
A Comparison Of Implant Stability Between Two Dental Implant Designusing Two Different Stability Measuring Technique, Chanikarn Chaksupa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective To investigate the primary stability of aggressive thread design implant comparing to nonaggressive thread design implant and to evaluate the correlation between ISQ values and IST values. Materials and methods 96 implants were used in this study. 48 BLT Straumann® and 48 BLX Straumann® were used. All implants were digitally planned and placed in 3D printed model using computer assisted guided surgery. The edentulous area at models were packed with randomized pattern of four different kinds of polyurethane blocks to replicate mixed cancellous bone. Postoperative implant stability measurement was performed immediately after implant insertion. Implant stability was measured by …
A Comparison Of Implant Stability Between Two Implant Systems Using Guided Surgery In Inexperienced Surgeons, Pinmuk Supachaiyakit
A Comparison Of Implant Stability Between Two Implant Systems Using Guided Surgery In Inexperienced Surgeons, Pinmuk Supachaiyakit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Aim: To investigate the implant stability in relation to two different implant designs, a cylindrical shaped single threaded design (CS/ST) and a tapered shaped double threaded design (TS/DT) using RFA over the first 8 weeks. Materials and Methods: 28 implants were randomly allocated into two groups and were placed as single tooth implant in the posterior arch. CBCT scan was used to determine the bone density and the implants were placed with guided surgical template by inexperienced surgeons which were prepared with the same implant planning software. The implant stability was measured using the RFA over the first 8 weeks …
Clinical Accuracy Between Planned And Placed Posterior Implant Position Of Two Static Implant Planning Software Programs In Inexperienced Operators, Wanwanat Singthong
Clinical Accuracy Between Planned And Placed Posterior Implant Position Of Two Static Implant Planning Software Programs In Inexperienced Operators, Wanwanat Singthong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This study aimed to evaluate and examine the difference in posterior implant positioning between the planned and placed positions when inexperienced operators used two static implant planning software packages following a fully guided implant surgery protocol in the clinical field. Materials and methods: Twenty-four patients who needed single posterior implant placement were randomly divided into two groups based on the used implant planning software (group 1, coDiagnostiX, n=12; group 2, Implant Studio, n=12). The dataset of the placed implant position, generated from digitizing the implant impression, was superimposed on the planned implant position. The number of horizontal, angular, and …
Effect Of Remaining Dentin Thickness And Primer Application Technique On Microtensile Bond Strength, Paphawee Somrit
Effect Of Remaining Dentin Thickness And Primer Application Technique On Microtensile Bond Strength, Paphawee Somrit
Chulalongkorn University Theses and Dissertations (Chula ETD)
To evaluate the effect of primer application techniques, type of adhesives and remaining dentin thicknesses on microtensile bond strength (µTBS) of 4 different adhesive systems, 112 Flat occlusal surfaces of sound third molar were randomly allocated into 16 groups based on 2 remaining dentin thicknesses (RDT), 2 application techniques and 3 adhesive systems, e.g., Three step etch-and-rinse (Optibond FL; OFL), Two step self-etch (Clearfil SE Bond; CSE), and Universal adhesive (Single Bond Universal; SB). SB was applied in either etch-and-rinse (ER) or self-etch (SE) mode. Simulated pulpal pressure was performed during bonding procedure and 6-month water storage (37 oC). After …
The Impact Of An Alkasite Restorative Material On The Ph Of A Streptococcus Mutans Biofilm And Dentin Remineralization: An In Vitro Study, Pawinee Wiriyasatiankun
The Impact Of An Alkasite Restorative Material On The Ph Of A Streptococcus Mutans Biofilm And Dentin Remineralization: An In Vitro Study, Pawinee Wiriyasatiankun
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigated the effect of an alkasite material on the pH of Streptococcus mutans biofilm and dentin hardness. S. mutans biofilms were formed on a resin composite (FZ) and an alkasite (CN) materials and their pH determined after 24 h. Hydroxide, fluoride and calcium ions released from the materials were determined at 6 h, 1, 3, 7, 14, and 28 d. Fourteen human molar teeth were cut horizontally across the middle third of the crown, bisected mesio-distally into two sections and each section divided into two, yielding four quadrants. Quadrant 1 was a sound dentin control, quadrants 2-4 were …
Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak
Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak
Chulalongkorn University Theses and Dissertations (Chula ETD)
The immunomodulatory property is to regulate immune cell function. IDO and TGF-β1 inhibited T cell proliferation and induced regulatory T (Treg) cells differentiation. However, this property must be activated by inflammation. Recently, mechanical forces have also activated this property. Hence, this study investigated effect of shear stress on immunosuppressive property of hPDL cells. Cells were subjected to shear stress then expression of IDO, TGF-β1, IFN-gamma and COX2 mRNA and protein was examined by qRT-PCR, ELISA, and IDO activity. Conditioned media derived shear stress were treated with CD4+ T cells. The proliferative T cell effect was determined using resazurin. The FOXP3, …
Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha
Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objectives of this research were 1) To investigate the allergic reactions to cannabidiol (CBD) when used on human skin. 2) To assess local and systemic side effects of CBD when used on normal oral mucosa. 3) To compare the efficacy among 0.1% CBD, 0.1% triamcinolone acetonide (TA), and placebo (pure oral paste) in recurrent aphthous ulcer (RAU) treatment. This project was composed of 3 phases. Phase 1, a skin patch test was performed on 100 healthy subjects. Phase 2, CBD was applied to normal oral mucosa of 50 healthy subjects 3 times/day for 7 days. Oral examination, vital signs, …
Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul
Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chemokines play pivotal roles in orthodontic tooth movement (OTM) through osteoclast-mediated bone resorption, but the underlying mechanism remains unclear. We aimed to elucidate the effects of serial local vs systemic administration of the chemokine receptor CXCR4 antagonist AMD3100 on OTM. The maxillary right first molar (M1) of rats was moved mesially using a 10 g of force nickel-titanium coil spring. The injections were performed every other day with phosphate-buffered saline as a control, whereas local and systemic animals were injected with AMD3100 at the buccal palatal mucosa adjacent to M1 and subcutaneously, respectively. OTM distance and alveolar bone were examined …
The Designs Of Miniscrew-Assisted Transpalatal Arch Affect Molar Intrusion, Ornnicha Pooktuantong
The Designs Of Miniscrew-Assisted Transpalatal Arch Affect Molar Intrusion, Ornnicha Pooktuantong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Abstract: An anterior open bite is one of the most difficult malocclusions in orthodontic treatment. For such malocclusion, orthodontic miniscrews insertion into both buccal and palatal alveolar regions has been indicated for molar intrusion, but it involves a risk of tooth root injury. To solve the problem, midpalatal miniscrew-attached extension arm (MMEA) is adopted. However, this method causes palatal tipping of the molar because intrusive loads were applied only from palatal side. Currently, transpalatal arch is added to avoid tipping movement, but it induces patient's discomfort. Hence, the objective of this study was to evaluate the loading conditions for maxillary …
Effects Of Intrauterine Intermittent Hypoxia On Skeletal Muscle In Offspring Rats, Wirongrong Wongkitikamjorn
Effects Of Intrauterine Intermittent Hypoxia On Skeletal Muscle In Offspring Rats, Wirongrong Wongkitikamjorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Gestational intermittent hypoxia (IH), a hallmark of OSA, alters the offspring's respiratory neural control and diaphragm contractile function. Thus, we aimed to investigate the effects of gestational IH on the muscle development and metabolism of geniohyoid (GH), which is innervated by the respiratory-related hypoglossal nerve and plays a role in tongue traction and suckling, in male offspring rats compared with masseter (MAS), the largest masticatory muscle. Pregnant Sprague-Dawley rats were exposed to IH (3-min periods of 4–21% O2) compared to Normoxia for 8 hours/day during gestational days 7–20. GH and MAS from 35-day-old male offspring (n = 6 /group) were …
The Efficacy Of Universal Ceramic Polishing Kit On The Surface Roughness Of Various Ceramic Types, Ekaluck Poosanthanasarn
The Efficacy Of Universal Ceramic Polishing Kit On The Surface Roughness Of Various Ceramic Types, Ekaluck Poosanthanasarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this vitro study was to determine the effect of polishing performance of a universal ceramic polishing kit on the surface roughness of various ceramics. The ceramic specimen size 5 x 7 x 4 mm of lithium disilicate glass ceramic (IPS e.max CAD, Ivoclar Vivadent, Liechtenstein), translucent zirconia (VITA YZ XT, VITA Zahnfabrik, Germany) and zirconia-reinforced lithium silicate (Celtra Duo, Dentsply Sirona, United States) (n=8) were fixed with clear resin in PVC block, 14 mm in diameter. The specimens were ground with fine diamond bur for 15 seconds to simulate clinical gross contouring.The two-step polishing process started with …
Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang
Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study evaluated the antifungal, physical, and mechanical properties of tissue conditioner incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) at different storage times (0, 7, and 14 days). Specimens of 0, 5, 10, 15 wt% ZnOnps, or 15 wt% nystatin incorporated into tissue conditioner were fabricated. The direct contact test (n=6) was performed to evaluate the antifungal effect against C. albicans suspension. Scanning electron microscopy and energy dispersive X-ray spectroscopy (n=6) were used to observe the amount and distribution of superficial zinc element. The penetration depth (n=6) and tensile bond strength (n=8) were evaluated following ISO 13139. The …
การศึกษาผลของวัสดุบูรณะที่ปลดปล่อยแร่ธาตุต่อการคืนแร่ธาตุในรอยผุระยะเริ่มต้น ของฟันกรามน้ำนมซี่ข้างเคียงในห้องปฏิบัติการ, ดนุธิดา สาเขตร์
การศึกษาผลของวัสดุบูรณะที่ปลดปล่อยแร่ธาตุต่อการคืนแร่ธาตุในรอยผุระยะเริ่มต้น ของฟันกรามน้ำนมซี่ข้างเคียงในห้องปฏิบัติการ, ดนุธิดา สาเขตร์
Chulalongkorn University Theses and Dissertations (Chula ETD)
การศึกษาในห้องปฏิบัติการนี้มีวัตถุประสงค์เพื่อเปรียบเทียบการคืนแร่ธาตุในรอยผุระยะเริ่มต้นของชิ้นฟันที่สัมผัสกับวัสดุบูรณะคลาสทูด้วยนาโนคอมโพสิตแคลเซียมฟอสเฟต (Predicta™ bioactive bulk) กับซีเมนต์กลาสส์ไอโอโนเมอร์ (Equia Forte®) และเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์ (Filtek™ Z350) เป็นกลุ่มควบคุม โดยใช้ชิ้นฟันน้ำนมจำนวน 60 ชิ้นจากด้านแก้มของฟันกรามน้ำนมที่ถูกถอน 60 ซี่มาสร้างรอยผุระยะเริ่มต้นที่กึ่งกลางของชิ้นฟัน นำชิ้นฟันตัวอย่างมาวัดร้อยละการสูญเสียฟลูออเรสเซนต์ (∆F) เริ่มต้นด้วยเครื่องวัดฟลูออเรสเซนต์ที่เกิดจากแสงเชิงปริมาณชนิดดิจิทัล เรียงลำดับร้อยละการสูญเสียฟลูออเรสเซนต์เริ่มต้นจากชิ้นฟันที่สูญเสียแร่ธาตุน้อยไปมาก สุ่มชิ้นฟันออกเป็น 3 กลุ่ม นำชิ้นฟันไปติดกับบล็อกอะคริลิกที่บูรณะด้านประชิดด้วยวัสดุบูรณะทั้ง 3 ชนิด แล้วเข้ากระบวนการเลียนแบบสภาวะในช่องปากเป็นเวลา 14 วัน จากนั้นวิเคราะห์ปริมาณการคืนแร่ธาตุโดยวัสดุบูรณะแต่ละชนิด ด้วยการเปรียบเทียบค่าเฉลี่ยของการเปลี่ยนแปลงร้อยละของการสูญเสียฟลูออเรสเซนต์ (∆∆F) และค่าเฉลี่ยของการเปลี่ยนแปลงปริมาตรการสูญเสียฟลูออเรสเซนต์ (∆∆Q) ผลการศึกษาพบว่าทั้งค่า ∆∆F และค่า ∆∆Q ของทุกกลุ่มมีความแตกต่างอย่างมีนัยสำคัญทางสถิติ โดยกลุ่มซีเมนต์กลาสส์ไอโอโนเมอร์ มีการคืนแร่ธาตุแก่ชิ้นฟันสูงที่สุด ส่วนกลุ่มนาโนคอมโพสิตแคลเซียมฟอสเฟตมีการสูญเสียแร่ธาตุของชิ้นฟันเล็กน้อย ซึ่งน้อยกว่ากลุ่มควบคุม คือเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์อย่างมีนัยสำคัญทางสถิติ สรุปได้ว่าการบูรณะด้วยวัสดุซีเมนต์กลาสไอโอโนเมอร์ สามารถคืนแร่ธาตุให้ฟันซี่ข้างเคียงได้ดีที่สุด แต่ในกรณีที่รอยผุหรือโพรงฟันคลาสทูมีขนาดใหญ่ นาโนคอมโพสิตแคลเซียมฟอสเฟตก็ถือเป็นวัสดุหนึ่งที่เป็นทางเลือกในการใช้ทดแทนเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์ เนื่องจากใช้งานง่าย มีความแข็งแรงและความสวยงามเทียบเท่ากับเรซินคอมโพสิต นอกจากนี้ยังช่วยยับยั้งการลุกลามของรอยผุระยะเริ่มต้นในฟันซี่ข้างเคียงได้ดีกว่าเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์