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The P2x7 Receptor Mediates Toxoplasma Gondii Control In Macrophages Through Canonical Nlrp3 Inflammasome Activation And Reactive Oxygen Species Production, Aline Cristina Abreu Moreira-Souza, Cassio Luiz Coutinho Almeida-Da-Silva, Thuany Prado Rangel, Gabrielle Da Costa Rocha, Maria Bellio, Dario Simões Zamboni, Rossiane Claudia Vommaro, Robson Coutinho-Silva
The P2x7 Receptor Mediates Toxoplasma Gondii Control In Macrophages Through Canonical Nlrp3 Inflammasome Activation And Reactive Oxygen Species Production, Aline Cristina Abreu Moreira-Souza, Cassio Luiz Coutinho Almeida-Da-Silva, Thuany Prado Rangel, Gabrielle Da Costa Rocha, Maria Bellio, Dario Simões Zamboni, Rossiane Claudia Vommaro, Robson Coutinho-Silva
All Dugoni School of Dentistry Faculty Articles
Toxoplasma gondii (T. gondii) is the protozoan parasite that causes toxoplasmosis, a potentially fatal disease to immunocompromised patients, and which affects approximately 30% of the world's population. Previously, we showed that purinergic signaling via the P2X7 receptor contributes to T. gondii elimination in macrophages, through reactive oxygen species (ROS) production and lysosome fusion with the parasitophorous vacuole. Moreover, we demonstrated that P2X7 receptor activation promotes the production of anti-parasitic pro-inflammatory cytokines during early T. gondii infection in vivo. However, the cascade of signaling events that leads to parasite elimination via P2X7 receptor activation remained to be elucidated. Here, we investigated …