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Full-Text Articles in Dentistry
Statins Regulate Il-1Β - Induced Rankl And Opg Production By Human Gingival Fibroblasts, Ivelina Jurkowski
Statins Regulate Il-1Β - Induced Rankl And Opg Production By Human Gingival Fibroblasts, Ivelina Jurkowski
Theses and Dissertations (ETD)
Three-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase competitive inhibitors, also known as statins, are widely used agents for lowering cholesterol and reducing the risk for a heart attack. Recent data suggest that statins influence bone metabolic activity by stimulating new bone formation both in vivo and in vitro. Bone resorption in periodontitis, an inflammatory disease, is orchestrated by the interaction of various cytokines in the inflamed tissue, produced by immune cells and also by resident cells such as human gingival fibroblasts (HGF) and periodontal ligament (PDL) cells. Three molecules, members of the tumor necrosis factor (TNF) ligand and receptor superfamilies, regulate the process of …