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Full-Text Articles in Dentistry
Chemotherapeutic Drug Resistance Associated With Differential Mirna Expression Of Mir-375 And Mir-27 Among Oral Cancer Cell Lines, Kieran Huni
UNLV Theses, Dissertations, Professional Papers, and Capstones
Objective: Although progress has been made towards the identification of molecular profiles that influence oral cancer growth and metastasis, recent advances have suggested that non-coding microRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of chemotherapeutic responsiveness. Based upon the paucity of information regarding this phenomenon, this project will determine whether these specific microRNAs are correlated with oral cancer responsiveness to chemotherapies, including Paclitaxel, Cisplatin and Fluorouracil (5FU).Methods: Commercially available and well-characterized oral squamous cell carcinoma cell lines (SCC4, SCC9, SCC15, SCC25 and CAL27) were used for this study. Experimental 96-well assays …
Differential Effects Of Extracellular Matrix Glycoproteins Fibronectin And Laminin-5 On Dental Pulp Stem Cell Phenotypes And Responsiveness, Hyungbin Lee
UNLV Theses, Dissertations, Professional Papers, and Capstones
Dental pulp stem cells (DPSCs) are mesenchymal stem cells (MSCs) with the potential to differentiate in a limited number of other tissue types. Some evidence has suggested the modulation of DPSC growth may be mediated, in part, by exogenous extracellular matrix (ECM) glycoproteins, including fibronectin (FN) and laminin-5 (LN5). Although preliminary research suggests that some ECM glycoproteins may work as functional biomaterials to modulate DPSC growth responses, the primary goal of this project is to determine the specific effects of FN and LN5 on DPSC growth and viability.Using an existing DPSC repository, n = 16 DPSC isolates were cultured and …
Dental Pulp Stem Cell Differentiation Potential Of Bmp-2 And Bmp-4, David Li
Dental Pulp Stem Cell Differentiation Potential Of Bmp-2 And Bmp-4, David Li
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction: Many studies are now evaluating the potential for dental pulp stem cells (DPSC) to assist with more complex and biotechnology applications, such as facilitating and promoting osseointegration following dental implants. However, the effects of factors that may control osseointegration and bone repair using DPSC including bone morphogenic proteins (BMP-2, BMP-4) are not yet well understood.Objective: Based upon this lack of evidence, the primary goal of this project is to evaluate the potential effects of BMPs (alone or in combination with other growth factors) to induce factors associated with osteogenesis. Methods: DPSC isolates from an existing repository (n = 13) …
Oral Prevalence Of Akkermancia Muciniphila Among Pediatric And Adult Orthodontic And Non-Orthodontic Patients, Ching Shen
UNLV Theses, Dissertations, Professional Papers, and Capstones
Akkermansia muciniphila (AM) is one of many highly abundant intestinal microbes that influences homeostasis and metabolic disorders and may also play a role in oral disorders. However, there is little evidence regarding the oral prevalence of this organism. Based upon this lack of evidence, the primary goal of this project is to survey an existing saliva repository to determine the overall prevalence of this organism and any associations with demographic or patient characteristics (age, sex, body mass index, race/ethnicity, orthodontic therapy). Using an approved protocol, a total n = 141 pediatric samples from an existing saliva repository were screened using …