Dentistry Commons^™

Dietary Quercetin And Kaempferol: Bioavailability And Potential Cardiovascular-Related Bioactivity In Humans, Wijdan M. Dabeek, Melissa Ventura Marra

Faculty & Staff Scholarship

Fruit and vegetable intake has been associated with a reduced risk of cardiovascular disease. Quercetin and kaempferol are among the most ubiquitous polyphenols in fruit and vegetables. Most of the quercetin and kaempferol in plants is attached to sugar moieties rather than in the free form. The types and attachments of sugars impact bioavailability, and thus bioactivity. This article aims to review the current literature on the bioavailability of quercetin and kaempferol from food sources and evaluate the potential cardiovascular effects in humans. Foods with the highest concentrations of quercetin and kaempferol in plants are not necessarily the most bioavailable …

Early Class Iii Treatment Decision-Making, Peter Ngan, David Musich

Faculty & Staff Scholarship

Clinicians make decisions for their patients everyday. Ryan Hamilton, in his course guidebook, How You Decide: The Science of Human Decision Making, summarized the current research on the 4 R's of decision-making that matter: reference points, reasons, resources, and replacement. The authors will apply this principle in the decision- making necessary for the growing Class III patients. First, the decision on whether to treat or not to treat Class III patients in the mixed dentition rely on a thorough diagnosis and objectives for early treatment. For example, elimination of a functional shift of the mandible may be a good …

Pilot Gwas Of Caries In African-Americans Shows Genetic Heterogeneity, E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. Mcneil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer

Faculty & Staff Scholarship

Background

Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African Americans has not been performed previously.

Methods

We performed exploratory GWAS of dental caries in 109 African American adults (age > 18) and 96 children (age 3–12) from the Center for Oral Health Research in Appalachia (COHRA1 cohort). Caries phenotypes (DMFS, DMFT, dft, and dfs indices) assessed by dental exams were tested for association …

Clinical And Microbiologic Investigation Of An Expedited Peri-Implantitis Dog Model: An Animal Study, Wook Jin Seong, Georgios Kotsakis, Jong-Ki Huh, Soo Cheol Jeong, Ki Young Nam, Jong Ryul Kim, Young Cheul Heo, Hyeon-Cheol Kim, Lei Zhang, Michael D. Evans, Heather Conrad, Robert J. Schumacher

Faculty & Staff Scholarship

Background: Animal studies are pivotal in allowing experimentation to identify efficacious treatment protocols for resolution of peri-implantitis. The purpose of this investigation was to characterize an expedited dog peri-implantitis model clinically, radiographically, and microbiologically. Methods: Eight hound dogs underwent extractions (week 0) and implant (3.3 × 8.5 mm) placement with simultaneous surgical defect creation and ligature placement for induction of peri-implantitis (week 10). Ligatures were replaced at 6 weeks (week 16) and removed after 9 weeks (week 19) when supporting bone loss involved approximately 50% of the peri-implant bone. Microbial samples from the defects and healthy control implant sites collected …