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Full-Text Articles in Dentistry
Salivary Mmp-9 In The Detection Of Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Mina D. Fahmy, Arndt Guentsch, Korosh Roshanghias, Joschka Hennings, Stefan Schultze-Mosgau
Salivary Mmp-9 In The Detection Of Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Mina D. Fahmy, Arndt Guentsch, Korosh Roshanghias, Joschka Hennings, Stefan Schultze-Mosgau
School of Dentistry Faculty Research and Publications
Background: Oral squamous cell carcinoma (OSCC) is the most common malignant tumour of the oral cavity. Detection of OSCC is currently based on clinical oral examination combined with histopathological evaluation of a biopsy sample. Direct contact between saliva and the oral cancer makes measurement of salivary metalloproteinase- 9 (MMP-9) an attractive alternative.
Material and Methods: In total, 30 OSCC patients and 30 healthy controls were included in this prospective study. Saliva samples from both groups were collected, centrifuged and supernatant fluid was subjected to ELISA for assessment of MMP-9. The median salivary MMP-9 values with interquartile range (IQR) of OSCC …