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Noor Hayaty Abu Kasim Abu Kasim N.H.
Dental pulp stromal cells; fetal bovine serum; human platelet lysate; large-scale expansion; regenerative medicine MESENCHYMAL STEM-CELLS; LONG-TERM EXPANSION; FETAL BOVINE SERUM; BONE-MARROW; CULTURE-CONDITIONS; IN-VITRO; GRADE PRODUCTION; DIFFERENTIATION; ADIPOGENESIS; OPTIMIZATION SELF-REPAIR; CULTURE-CONDITIONS; COMPOSITE RESIN; DENTAL PULP STEM CELL; FUNCTIONALLY GRADED DESIGN; MULTI LAYERED POST; FUNCTIONALLY GRADED DENTAL POST; SOFT SKILLS; CLINICAL PAIRING; DENTAL PULP STROMAL CELLS; LONG-TERM EXPANSION
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Full-Text Articles in Dentistry
Human Platelet Lysate Permits Scale-Up Of Dental Pulp Stromal Cells For Clinical Applications, Noor Hayaty Abu Kasim Abu Kasim N.H.
Human Platelet Lysate Permits Scale-Up Of Dental Pulp Stromal Cells For Clinical Applications, Noor Hayaty Abu Kasim Abu Kasim N.H.
Noor Hayaty Abu Kasim Abu Kasim N.H.
Background aims. Dental pulp stromal cells (DPSC) are considered to be a promising source of stem cells in the field of regenerative therapy. However, the usage of DPSC in transplantation requires large-scale expansion to cater for the need for clinical quantity without compromising current good manufacturing practice (cGMP). Existing protocols for cell culturing make use of fetal bovine serum (FBS) as a nutritional supplement. Unfortunately, FBS is an undesirable additive to cells because it carries the risk of transmitting viral and prion diseases. Therefore, the present study was undertaken to examine the efficacy of human platelet lysate (HPL) as a …