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Efficacy Of N-Acetylcysteine On Prevention And Amelioration Of Cisplatin-Induced Ototoxicity: A Systematic Literature Review, Maryana Peravozchykava
Efficacy Of N-Acetylcysteine On Prevention And Amelioration Of Cisplatin-Induced Ototoxicity: A Systematic Literature Review, Maryana Peravozchykava
Dissertations, Theses, and Capstone Projects
Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.
Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.
Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.
Discussion: The significant variability in findings on NAC otoprotective efficacy …