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Full-Text Articles in Medicine and Health Sciences
Lymph Node But Not Intradermal Injection Site Macrophages Are Critical For Germinal Center Formation And Antibody Responses To Rabies Vaccination., Andrew G Lytle, Shixue Shen, James Mcgettigan
Lymph Node But Not Intradermal Injection Site Macrophages Are Critical For Germinal Center Formation And Antibody Responses To Rabies Vaccination., Andrew G Lytle, Shixue Shen, James Mcgettigan
Department of Microbiology and Immunology Faculty Papers
UNLABELLED: Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV infections, we studied the role of macrophages as mediators of RABV-based vaccine immunogenicity. In this report, we show that a recombinant matrix gene-deleted RABV-based vaccine (rRABV-ΔM) infects and activates primary murine macrophages in vitro. Immunization of mice with live RABV-based vaccines results in accumulation of macrophages at the site of immunization, which suggests that macrophages in tissues support the development of effective anti-RABV B cell responses. However, we show that …
The Onchocerciasis Vaccine For Africa-Tova-Initiative., Peter J Hotez, Maria Elena Bottazzi, Bin Zhan, Benjamin L Makepeace, Thomas R Klei, David Abraham, David W Taylor, Sara Lustigman
The Onchocerciasis Vaccine For Africa-Tova-Initiative., Peter J Hotez, Maria Elena Bottazzi, Bin Zhan, Benjamin L Makepeace, Thomas R Klei, David Abraham, David W Taylor, Sara Lustigman
Department of Microbiology and Immunology Faculty Papers
No abstract provided.