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Urogenital Abnormalities In Men Exposed To Diethylstilbestrol In Utero: A Cohort Study, Julie R. Palmer, Arthur L. Herbst, Kenneth L. Noller, Deborah A. Boggs, Rebecca Troisi, Linda Titus-Ernstoff, Elizabeth E. Hatch, Lauren A. Wise, William C. Strohsnitter, Robert N. Hoover
Urogenital Abnormalities In Men Exposed To Diethylstilbestrol In Utero: A Cohort Study, Julie R. Palmer, Arthur L. Herbst, Kenneth L. Noller, Deborah A. Boggs, Rebecca Troisi, Linda Titus-Ernstoff, Elizabeth E. Hatch, Lauren A. Wise, William C. Strohsnitter, Robert N. Hoover
Dartmouth Scholarship
Background: Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the 1940s70s, has been shown to cause reproductive problems in the daughters. Studies of prenatally-exposed males have yielded conflicting results.
Methods: In data from a collaborative follow-up of three U.S. cohorts of DES-exposed sons, we examined the relation of prenatal DES exposure to occurrence of male urogenital abnormalities. Exposure status was determined through review of prenatal records. Mailed questionnaires (1994, 1997, 2001) asked about specified abnormalities of the urogenital tract. Risk ratios (RR) were estimated by Cox regression with constant time at risk and control for year of …