Medicine and Health Sciences Commons^™

Efficacy Of An Enhanced Implementation Strategy To Increase Parent Engagement With A Health Promotion Program In Childcare, Courtney T. Luecking, Cody D. Neshteruk, Stephanie Mazzucca, Dianne S. Ward

Dietetics and Human Nutrition Faculty Publications

Previous efforts to involve parents in implementation of childcare-based health promotion interventions have yielded limited success, suggesting a need for different implementation strategies. This study evaluated the efficacy of an enhanced implementation strategy to increase parent engagement with Healthy Me, Healthy We. This quasi-experimental study included childcare centers from the second of two waves of a cluster-randomized trial. The standard approach (giving parents intervention materials, prompting participation at home, inviting participation with classroom events) was delivered in 2016–2017 (29 centers, 116 providers, and 199 parents). The enhanced approach (standard plus seeking feedback, identifying and addressing barriers to parent participation) …

The Effects Of Physical Activity On Cancer Patients Undergoing Treatment With Immune Checkpoint Inhibitors: A Scoping Review., Amy L Shaver, Swapnil Sharma, Nikita Nikita, Daniel S Lefler, Atrayee Basu-Mallick, Jennifer M Johnson, Meghan Butryn, Grace Lu-Yao

Department of Medical Oncology Faculty Papers

BACKGROUND: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy.

METHOD: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.

RESULTS: …

The Effects Of Physical Activity On Cancer Patients Undergoing Treatment With Immune Checkpoint Inhibitors: A Scoping Review, Amy L Shaver, Swapnil Sharma, Nikita Nikita, Daniel S Lefler, Atrayee Basu Mallick, Jennifer Johnson, Meghan Butryn, Grace Lu-Yao

Department of Medical Oncology Faculty Papers

Background: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy.

Method: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.

Results: …

Fatigue In Rheumatoid Arthritis Benchmark Study, Devan C. Salone

MSN Capstone Projects

Fatigue is perceived as one of the dominant symptoms of Rheumatoid Arthritis (RA) along with the pain that affects activities of daily life. RA-related fatigue was also described as unpredictable in its severity, duration, frequency, and intensity (Primdahl et al., 2019). The fatigue can mean feeling overwhelmed with feeling tired, unmotivated, increased pain, lack of concentration, or not getting enough sleep to combat the feeling of being tired (Choy & Dures, 2019). According to Widemark (2014), it is estimated that 40% to nearly 90% of RA patients experience chronic fatigue. The fatigue can happen at any time with RA. It …

Parents’ Report Of Canadian Elementary School Children’S Physical Activity And Screen Time During The Covid-19 Pandemic: A Longitudinal Study, Emma Ostermeier, Patricia Tucker, Andrew Clark, Jamie A. Seabrook, Jason Gilliland

Paediatrics Publications

COVID-19 public health protocols have altered children’s daily routines, limiting their physical activity opportunities. The purpose of this study was to examine how the COVID-19 pandemic affected children’s (ages 10–12 years) physical activity and screen time, and to explore the impact of gender, socioeconomic status (SES), and public health constraints (i.e., facility use and social interaction) on the changes in children’s health behaviors. Online surveys were disseminated to parents at two time points: before COVID-19 (May 2019 to February 2020) and during COVID-19 (November to December 2020). Wilcoxon signed-rank tests were used to assess changes in physical activity and screen …

The Efficacy Of A Personalized Mhealth Coaching Program During Pregnancy On Maternal Diet, Supplement Use, And Physical Activity: Protocol For A Parallel-Group Randomized Controlled Trial, Rozina Nuruddin, Khadija Vadsaria, Nuruddin Badruddin Mohammed, Saleem Sayani

Community Health Sciences

Background: Adequate intake of macro- and micronutrients and adoption of an active lifestyle during pregnancy are essential for optimum maternal and fetal health and offspring development. Dietary counseling and advice regarding adequate physical activity are integral components of antenatal care. Personalized coaching through the use of mobile health (mHealth) that supports behavior modification is an innovative approach that needs exploration.
Objective: Our primary aim is to assess the efficacy of an mHealth program in improving diet, supplement use, and physical activity during pregnancy. Secondary objectives include evaluation of the program's effect on maternal and offspring health outcomes and assessment of …

Healthy Eating And Physical Activity Among New Graduate Nurses: A Qualitative Study Of Barriers And Enablers During Their First Year Of Clinical Practice, Elizabeth Brogan, Chris Rossiter, Christine Duffield, Elizabeth Denney-Wilson

Research outputs 2014 to 2021

Background: New graduate nurses entering the workforce experience numerous barriers to maintaining a healthy lifestyle including shift work, the high cost of healthy foods at the workplace and high levels of exhaustion which reduce motivation to participate in regular physical activity. Research has documented unhealthy lifestyles among nurses across the profession. However, few studies focus on graduates' experiences during their transition into their careers. Aim: To investigate the barriers and enablers to healthy eating and participation in physical activity for new graduate nurses during their first year of clinical practice, and to explore attitudes to participation in workplace health promotion …

A Prospective Observational Study Of Antihemophilic Factor (Recombinant) Prophylaxis Related To Physical Activity Levels In Patients With Hemophilia A In The United States (Space), Barbara A. Konkle, Doris V. Quon, Leslie Raffini, Michael Recht, Vlad C. Radulescu, Shannon L. Carpenter, Amy L. Dunn, Mei Lu, Maureen Watt

Pediatrics Faculty Publications

Introduction: High collision-risk physical activity can increase bleeding risk in people with hemophilia A, as can increasing the time between factor VIII (FVIII) administration and physical activity. FVIII prophylaxis may be tailored to planned activities to prevent activity-related bleeding.

Aim: To explore the relationship between physical activity levels, FVIII infusion timing, and occurrence of bleeding in patients with severe/moderately severe hemophilia A without FVIII inhibitors receiving antihemophilic factor (recombinant) (rAHF; ADVATE^®; Baxalta US Inc., a Takeda company, Lexington, MA, USA).

Methods: SPACE was a 6-month, prospective, multicenter, observational outcomes study (NCT02190149). Enrolled patients received an eDiary application and …

A Prospective Observational Study Of Antihemophilic Factor (Recombinant) Prophylaxis Related To Physical Activity Levels In Patients With Hemophilia A In The United States (Space)., Barbara A. Konkle, Doris V. Quon, Leslie Raffini, Michael Recht, Vlad C. Radulescu, Shannon L. Carpenter, Amy L. Dunn, Mei Lu, Maureen Watt

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: High collision-risk physical activity can increase bleeding risk in people with hemophilia A, as can increasing the time between factor VIII (FVIII) administration and physical activity. FVIII prophylaxis may be tailored to planned activities to prevent activity-related bleeding.

Aim: To explore the relationship between physical activity levels, FVIII infusion timing, and occurrence of bleeding in patients with severe/moderately severe hemophilia A without FVIII inhibitors receiving antihemophilic factor (recombinant) (rAHF; ADVATE®; Baxalta US Inc., a Takeda company, Lexington, MA, USA).

Methods: SPACE was a 6-month, prospective, multicenter, observational outcomes study (NCT02190149). Enrolled patients received an eDiary application and …

Integration Of Consumer-Based Activity Monitors Into Clinical Practice For Children With Type 1 Diabetes: A Feasibility Study, Jason R. Jaggers, Timothy Mckay, Kristi M. King, Bradly J. Thrasher, Kupper A. Wintergerst

Faculty Scholarship

Current technology commonly utilized in diabetes care includes continuous glucose monitors (CGMs) and insulin pumps. One often overlooked critical component to the human glucose response is daily physical activity habits. Consumer-based activity monitors may be a valid way for clinics to collect physical activity data, but whether or not children with type 1 diabetes (T1D) would wear them or use the associated mobile application is unknown. Therefore, the purpose of this study was to test the feasibility of implementing a consumer-based accelerometer directly into ongoing care for adolescents managing T1D. Methods: Adolescents with T1D were invited to participate in this …

What Sets Physically Active Rural Communities Apart From Less Active Ones? A Comparative Case Study Of Three Us Counties, Christiaan G. Abildso, Cynthia K. Perry, Lauren Jacobs, M. Renée Umstattd Meyer, Megan Mcclendon, Michael B. Edwards, James N. Roemmich, Zachary Ramsey, Margaret Stout

Faculty & Staff Scholarship

Background: Rural US communities experience health disparities, including a lower prevalence of physical activity (PA). However, “Positive Deviants”—rural communities with greater PA than their peers—exist. The purpose of this study was to identify the factors that help create physically active rural US communities. Methods: Stakeholder interviews, on-site intercept interviews, and in-person observations were used to form a comparative case study of two rural counties with high PA prevalence (HPAs) and one with low PA prevalence (LPA) from a southern US state, selected based on rurality and adult PA prevalence. Interview transcripts were inductively coded by three readers, resulting in a …

Influences Of Balance Confidence, Fear Of Falling, And Fall History On Physical Activity Levels In Community-Dwelling Older Adults, Alison Yang Spt, Holly Roberts Pt, Phd

Physical Therapy Research Symposium

Background: Physical activity levels generally decline with increasing age. Few studies have examined the influences of balance confidence, fear of falling, and fall history on physical activity levels in older adults.

Purpose: To determine the relationships between balance confidence, fear of falling, fall history, and physical activity level in community-dwelling older adults.

Methods: Eighty-eight participants completed the Activities-specific Balance Confidence Scale (ABC), Fear of Falling Avoidance Behavior Questionnaire (FFABQ), and a self-reported fall history. They reported their monthly activity levels using the Physical Activity Scale for the Elderly (PASE). Pearson correlation coefficients (r) were used to analyze …

Can Learning Be Enhanced With Active Seating?, Judy Beard, Kirk Mathias

All Faculty Scholarship for the College of Education and Professional Studies

Overweightness continues to increase at an exponential rate in children. This coupled with the demand to increase academic time in elementary schools has contributed to efforts to discover solutions that meet both challenges. Potential solutions are movement curricula and active seating options. However, little has been published relative to best practices of their implementation. Therefore, the purpose of this paper is to discuss the lessons learned while utilizing pedal desks in first and second grade classrooms as stations and whole class seating. Additionally, two different types of heart rate monitors (Polar Oh1 and IHT Spirit) were employed, in an attempt …

Current And Future Implications Of Covid-19 Among Youth Wheelchair Users: 24-Hour Activity Behavior, Ryan T. Conners, Lauren C. Bates, Patricia Pagan Lassalle, Gabriel Zieff, Paul N. Whitehead, Sandra Stevens, Lauren Killen, Robert Cochrum, Kathryn L. Rodebaugh, Mark Faghy, Lee Stoner

Human Performance and Sport Sciences faculty Research

Preventative measures taken worldwide to decrease the transmission of COVID-19 have had a tremendous impact on youth. Following social restrictions, youth with and without physical disabilities are engaging in less physical activity, more increased sedentary behavior, and poor sleep habits. Specifically, youth wheelchair users (YWU) are likely disproportionately affected by COVID- 19 and have a higher risk of contraction due to underlying comorbidities. While we cannot control all of the negative long-term implications of COVID-19 for YWU, participation in positive 24-h activity behaviors can decrease chronic disease risk and the likelihood of long-term complications resulting from infection. This commentary is …

The Association Between Motor Capacity And Motor Performance In School-Aged Children With Cerebral Palsy: An Observational Study, Min-Hwa Suk, In-Kyeong Park, Soojin Yoo, Jeong-Yi Kwon

Health & Human Performance Faculty Publications and Presentations

Background

This study aimed to investigate the association between motor capacity and motor performance in children with cerebral palsy (CP) aged 6–12 years with Gross Motor Function Classification System (GMFCS) levels I to III.

Methods

Forty-six children with CP (24 boys and 22 girls) classified as GMFCS levels Ⅰ, Ⅱ, or Ⅲ were included. Motor capacity was measured by the Gross motor function measure (GMFM), Pediatric balance scale (PBS), Timed up and go (TUG), and 6-min walk test (6MWT). Motor performance was measured by triaxial accelerometers. Estimations of physical activity energy expenditure (PAEE) (kcal/kg/day), percentage of time spent on …

Stair Versus Elevator Use In A University Residence Hall Setting, Vincent Berardi, Benjamin D. Rosenberg, Sophie Srivastava, Noah Estrada-Rand, Julia Frederick

Psychology Faculty Articles and Research

Objective

Determine the temporal and spatial characteristics of stairs versus elevator use in a university residence hall to inform future physical activity promotion efforts.

Participants

All residents and visitors for a single, four-story residence hall dormitory building located on a college campus in Orange, CA.

Methods

Smart mat systems capable of detecting pedestrian traffic were placed in front of the stairs and elevators on each floor plus a basement. Generalized additive mixed models (GAMMs) were used to compare stair versus elevator usage at different times of the day and on different floors.

Results

Stair versus elevator use varied much more …

Physical Activity Barriers And Assets In Rural Appalachian Kentucky: A Mixed-Methods Study, Natalie Jones, Deirdre Dlugonski, Rachel Gillespie, Emily M. Dewitt, Joann Lianekhammy, Stacey A. Slone, Kathryn M. Cardarelli

Sports Medicine Research Institute Faculty Publications

Obesity is an increasing public health concern in the U.S. and a contributor to chronic illness, with trends revealing a rise in adult obesity and chronic disease rates among the most vulnerable and disadvantaged populations, including those in rural communities. A mixed-methods approach was used to examine perspectives on perceived physical activity barriers, resources, and level of community support. Researchers utilized the socioecological model to examine the multiple domains that support physical activity in rural Appalachia. The present study focuses on baseline data, including a cohort survey to assess physical activity, health status, and barriers to physical activity, and five …

Association Between Physical Activity And Sport Participation On Hemoglobin A1c Among Children And Adolescents With Type 1 Diabetes, Kristi King, Jason R. Jaggers, Lindsay J. Della, Timothy Mckay, Sara Watson, Amy E. Kozerski, Kimberly Hartson, Kupper A. Wintergerst

Faculty Scholarship

Purpose: To determine associations between physical activity (PA) and sport participation on HbA1c levels in children with type 1 diabetes (T1D). Method: Pediatric patients with T1D were invited to complete a PA and sport participation survey. Data were linked to their medical records for demographic characteristics, diabetes treatment and monitoring plans, and HbA1c levels. Results: Participants consisted of 71 females and 81 males, were 13 +- 3 years old with an average HbA1c level of 8.75 +- 1.81. Children accumulating 60 min of activity 3 days or more a week had significantly lower HbA1c compared to those who accumulated less …

Household Food Insecurity And Children’S Physical Activity And Sedentary Behaviour In The United States: The Healthy Communities Study, Sophia M. Navarro, Marisa M. Tsai, Lorrene D. Ritchie, Edward A. Frongillo Jr., Barbara A. Laraia, Russell R. Pate, Lauren E. Au

Faculty Publications

OBJECTIVE: To examine associations between household food insecurity and children's physical activity and sedentary behaviours. DESIGN: Secondary analysis was conducted on the Healthy Communities Study, an observational study from 2013 to 2015. Household food insecurity was assessed by two items from the US Department of Agriculture's 18-item US Household Food Security Survey Module. Physical activity was measured using the 7-d Physical Activity Behavior Recall instrument. Data were analyzed using multilevel statistical modelling. SETTING: A total of 130 communities in the USA. PARTICIPANTS: In sum, 5138 US children aged 4-15 years. RESULTS: No associations were found for the relationship between household …

Evaluating The Effects Of Physical Activity On The Cognitive Functions And Motor Skills Of The Special Needs Population And Testing A Different Teaching Style To Maximize The Efficiency Of Special Needs Programs, Oren Nedjar

BIO4960: Practicum in Biology I

This study aimed to analyze the effects of physical activities on the motor and cognitive functions of participants with special needs and compare these results with a similar program but organized online because of the health precautions that have been applied due to the COVID-19 pandemic. An intervention consisting of sending an educational brochure aiming to increase high school volunteers' health literacy was then tested and results showed that it improved participants' health outcomes and also could increase the program's effectiveness in the long term.

Livewell In Early Childhood: Results From A Two-Year Pilot Intervention To Improve Nutrition And Physical Activity Policies, Systems And Environments Among Early Childhood Education Programs In South Carolina, Meghan Slining, Sally Wills, Melissa Fair, Jen Stephenson, Stephanie Knobel, Misty Pearson, Tia Prostko, Joanna Smyers, Joanne Timberlake, Miguel Negrete

Open Access Fund Publications

Background

Early childhood education (ECE) settings are critical intervention targets for obesity prevention. This study evaluated a pilot two-year community-based participatory research (CBPR) project designed to assist ECE center directors and caregivers in policy, systems and environmental (PSE) change for improving healthy eating (HE) and physical activity (PA).

Methods

A two-year CBPR study was conducted in 10 licensed ECE centers in Greenville, South Carolina. The intervention consisted of five steps: [1] baseline data collection and self-assessment using the Nutrition and Physical Activity Self-Assessment for Child Care (Go-NAP SACC), [2] tailored goal setting and action planning, [3] technical assistance and access …

Home And Neighborhood Physical Activity Location Availability Among African American Adolescent Girls Living In Low-Income, Urban Communities: Associations With Objectively Measured Physical Activity, Nicole O'Reilly

Social Work Faculty Publications and Presentations

Based on the ecological model of active living, the neighborhood environment may relate to individual physical activity (PA) behaviors. The purposes of this study were to (1) generate a replicable neighborhood-level physical activity location availability score (PALAS) from data variables associated with physical activity among adolescents and adults, and apply this score to Baltimore City, Maryland, and (2) determine if relationships exist between PA and PA location availability. Geographic information systems (GISs) were used to create the PALAS. Using linear regression models, we examined relations between objectively measured PA among low-income, urban, predominantly African American adolescent girls (n = …

Obstetric Patients And Healthcare Providers Perspectives To Inform Mobile App Design For Physical Activity And Weight Control During Pregnancy And Postpartum In A Rural Setting, Rachel Tinius, Cathryn Duchette, Sia Beasley, Maire Blankenship, Nancy Schoenberg

Behavioral Science Faculty Publications

Background: Mobile health technology offers the opportunity for women to engage with physical activity promotion programs without many of the barriers commonly associated with exercise during and after pregnancy (eg, childcare concerns, rigid schedules, fear of doing harm to fetus or self, access to fitness facilities, uncomfortable with body in front of others) which may be particularly useful in under-resourced rural environments. We conducted the first known study on perspectives of pregnant women, postpartum women, and obstetric healthcare providers in a rural setting on needs related to the development of a mobile app designed to increase physical activity during pregnancy …

Cannabis Use, Sedentary Behavior, And Physical Activity In A Nationally Representative Sample Of Us Adults, Lydia Q. Ong, John Belletierre, Citlali Alvorado, Paul Chavez, Vincent Berardi

Psychology Faculty Articles and Research

Background

Prior research examining the relationship between cannabis use, sedentary behavior, and physical activity has generated conflicting findings, potentially due to biases in the self-reported measures used to assess physical activity. This study aimed to more precisely explore the relationship between cannabis use and sedentary behavior/physical activity using objective measures.

Methods

Data were obtained from the 2005–2006 National Health and Nutrition Examination Survey. A total of 2,092 participants (ages 20–59; 48.8% female) had accelerometer-measured sedentary behavior, light physical activity, and moderate-to-vigorous physical activity. Participants were classified as light, moderate, frequent, or non-current cannabis users depending on how often they used …

Sport And Physical Activity During The First 10 Years Of Life In Ireland And The Uk, Kristy Howells, Tara Coppinger

Pre-prints

This chapter considers the many similarities within the educational experiences of the young children in sport and physical activity (PA) in Ireland and the United Kingdom (UK). PA has, in both countries, had an increased focus on its value and importance within children’s lives, a time of habit development. Public Health England (2014) reported that one in six deaths in the UK are due to lack of PA in adults, making it as dangerous as smoking. Healthy Ireland is the national framework for action to improve the health and wellbeing of the people of Ireland. The national guidelines for 2- …

Application Of The Ideas Framework In Adapting A Web-Based Physical Activity Intervention For Young Adult College Students, Kimberly R. Hartson, Lindsay J. Della, Kristi King, Sam Liu, Paige N. Newquist, Ryan E. Rhodes

Faculty Scholarship

User-centered developmental processes are critical to ensuring acceptability of e-health behavioral interventions, and yet physical activity research continues to be inundated with top-down developmental approaches. The IDEAS (Integrate, Design, Assess, and Share) framework outlines a user-centered process for development of e-health interventions. The purpose of this manuscript is to describe the application of the IDEAS framework in adapting a web-based physical activity intervention for young adult college students. Steps 1–3 emphasized integrating insights from users and theory and Steps 4–7 focused on iterative and rapid design with user feedback. Data were collected via repeat qualitative interviews with young adult college …

Energy Cost Of Walking And Functional Aerobic Capacity During Moderate Intensity Exercise In Adults With Obstructive Sleep Apnea: A Cross-Sectional Study, Jeffrey E. Herrick Phd

Faculty Publications

Background: Autonomic dysregulation associated with obstructive sleep apnea (OSA) may limit cardiopulmonaryresponses to exercise, which, in turn, may impair functional aerobic capacity (FAC) and walking economy. Weaimed to characterize walking economy and FAC in OSA patients compared with healthy adults (non-OSA) andexamine their relationship with OSA severity (apnea-hypopnea index [AHI]).

Methods: A total of 26 adults (OSA,n= 13; non-OSA,n= 13) participated in this cross-sectional study. In this study,the participants with OSA were between the ages of 25 and 60 years, with a body mass index of 25 kg/m2to 39 kg/m2, and who had undergone a recent third-party sleep study with …

Prehabilitation Prior To Cabg, Casey Bunker, Neil Peterson

Student Works

Background and Purpose: Globally, coronary artery disease (CAD) affects 126.5 million adults. To decrease mortality, coronary artery bypass graft (CABG) surgeries are often performed. CABGs have inherent risks such as financial burden, physical complication, and emotional stress. Cardiac rehabilitation programs help decrease complications postoperatively. However, few interventions are performed preoperatively. Prehabilitation (prehab) programs have been created to address this gap in other types of surgeries. Prehab is the purposeful implementation of physical activity before a procedure to improve perioperative outcomes. Prehab prior to CABG has not been well studied previously. Furthermore, it is unknown if families should support a sedentary …

Impact Of Covid-19 On Mental Health And Quality Of Life: Is There Any Effect? A Crosssectional Study Of The Mena Region, Ayesha S. Al Dhaheri, Mo'ath F. Bataineh, Maysm N. Mohamad, Abir Ajab, Amina Al Marzouqi, Amjad H. Jarrar, Carla Habib-Mourad, Dima O.Abu Jamous, Habiba I. Ali, Haleama Al Sabbah, Hayder Hasan, Lily Stojanovska, Mona Hashim, Osama A.Abd Elhameed, Reyad R.Shaker Obaid, Samar Elfeky, Sheima T. Saleh, Tareq M. Osaili, Leila Cheikh Ismail

All Works

The COVID-19 pandemic is a major health crisis that has changed the life of millions globally. The purpose of this study was to assess the effect of the pandemic on mental health and quality of life among the general population in the Middle East and North Africa (MENA) region. A total of 6142 adults from eighteen countries within the MENA region completed an online questionnaire between May and June 2020. Psychological impact was assessed using the Impact of Event Scale-Revised (IES-R) and the social and family support impact was assessed with questions from the Perceived Support Scale (PSS). The IES-R …

Multimodal Imaging Brain Markers In Early Adolescence Are Linked With A Physically Active Lifestyle, Piergiorgio Salvan, Thomas Wassenaar, Catherine Wheatley, Nicholas Beale, Michiel Cottaar, Daniel Papp, Matteo Bastiani, Sean P. Fitzgibbon, Euguene Duff, Anderson M. Winkler

School of Medicine Publications and Presentations

The World Health Organization promotes physical exercise and a healthy lifestyle as means to improve youth development. However, relationships between physical lifestyle and human brain development are not fully understood. Here, we asked whether a human brain-physical latent mode of covariation underpins the relationship between physical activity, fitness, and physical health measures with multimodal neuroimaging markers. In 50 12-year old school pupils (26 females), we acquired multimodal whole-brain MRI, characterizing brain structure, microstructure, function, myelin content, and blood perfusion. We also acquired physical variables measuring objective fitness levels, 7 d physical activity, body mass index, heart rate, and blood pressure. …