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Identifying A Novel Role For Fractalkine (Cx3cl1) In Memory Cd8(+) T Cell Accumulation In The Omentum Of Obesity-Associated Cancer Patients, Melissa J. Conroy, Stephen G. Maher, Ashanty M. Ashanty, Suzanne Doyle, Emma K. Foley, John V. Reynolds, Aideen Long, Joanne Lysaght
Identifying A Novel Role For Fractalkine (Cx3cl1) In Memory Cd8(+) T Cell Accumulation In The Omentum Of Obesity-Associated Cancer Patients, Melissa J. Conroy, Stephen G. Maher, Ashanty M. Ashanty, Suzanne Doyle, Emma K. Foley, John V. Reynolds, Aideen Long, Joanne Lysaght
Articles
The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key player in their active migration to this inflamed tissue. More recently, others have established that subsets of memory CD8+ T cells can be classified based on their surface expression of CX3CR1; the specific receptor for the inflammatory chemokine fractalkine. CD8+ T cells expressing intermediate levels (CX3CR1INT) are defined as peripheral memory, those expressing the highest levels (CX3CR1HI) are effector memory/terminally differentiated and those lacking CX3CR1 (CX3CR1NEG) are classified …