Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Dissertations, 2014-2019
Sound localization is an important aspect of normal hearing. The Eph/ephin family of signaling proteins, studied here, is known to guide the formation of central auditory connections in early development, particularly topographic inputs from the lateral superior olive (LSO) to the inferior colliculus (IC). Processing in the LSO and its influences on the IC are known to be heavily involved in sound localization tasks. One way to study sound localization in mice is through pre-pulse inhibition (PPI). PPI is the phenomenon by which a weak prestimulus inhibits the response to a subsequent startle stimulus. In studying sound localization, the prestimulus …